SCHEMBL13839983

SCHEMBL13839983

C=COc1ccc(N(c2ccc(OC=C)cc2)c2ccc(OC=C)cc2)cc1

nearest known ligand 0.31

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
MAPT P10636 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12925273 0.91 ALDH1A1 (0.45) KDM4EALDH1A1CYP1A2CYP3A4CYP2D6
SCHEMBL2602563 0.89
SCHEMBL20090478 0.86 ALDH1A1 (0.36) KDM4EALDH1A1CYP1A2CYP3A4CYP2D6
SCHEMBL13839987 0.84 ALDH1A1 (0.39) ALDH1A1MAPT
SCHEMBL20090502 0.84 TSHR (0.34) ALDH1A1CYP3A4MAPT
SCHEMBL12925307 0.84 ALDH1A1 (0.39) KDM4EALDH1A1CYP1A2CYP3A4CYP2D6
SCHEMBL473606 0.84 CHRNB2 (0.34) ALDH1A1CYP3A4MAPT
SCHEMBL3394069 0.81 ALDH1A1 (0.50) KDM4EALDH1A1CYP3A4MAPTTDP1
SCHEMBL13839956 0.80 TSHR (0.37)
SCHEMBL2602565 0.78

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7534534-B2 Electrophotographic Photosensitive member, method for manufacturing electrophotographic photosensitive member, process cartridge and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2009-05-19 US disclosed
US-7534534-B2 Electrophotographic Photosensitive member, method for manufacturing electrophotographic photosensitive member, process cartridge and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2009-05-19 US disclosed
US-7378205-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2008-05-27 US disclosed
US-7378205-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2008-05-27 US disclosed
US-7272344-B2 Image forming method capable of maintaining sustained stable cleaning performance without causing an image smearing phenomenon even with a high strength and high abrasion image bearing member CANON KABUSHIKI KAISHA (JP) 2007-09-18 US disclosed
US-7272344-B2 Image forming method capable of maintaining sustained stable cleaning performance without causing an image smearing phenomenon even with a high strength and high abrasion image bearing member CANON KABUSHIKI KAISHA (JP) 2007-09-18 US disclosed
US-7226711-B2 Electrophotographic photosensitive member, method for manufacturing electrophotographic photosensitive member, process cartridge and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2007-06-05 US disclosed
US-7226711-B2 Electrophotographic photosensitive member, method for manufacturing electrophotographic photosensitive member, process cartridge and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2007-06-05 US disclosed
US-7186489-B2 Electrophotographic photosensitive member, electrophotographic photosensitive member manufacturing process, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2007-03-06 US disclosed
US-7186489-B2 Electrophotographic photosensitive member, electrophotographic photosensitive member manufacturing process, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2007-03-06 US disclosed