Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | SNCA | P37840 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.35 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3925046 | 1.00 | PARP1 (0.41) | PARP1LMNAGAAOPRM1OPRD1 | |
| SCHEMBL13840618 | 0.89 | PARP1 (0.42) | PARP1LMNAGAASNCANPC1 | |
| SCHEMBL3917123 | 0.89 | PARP1 (0.42) | PARP1LMNAGAASNCANPC1 | |
| SCHEMBL4387621 | 0.88 | ADRB2 (0.47) | PARP1LMNAGAASNCANAMPT | |
| SCHEMBL4387615 | 0.88 | ADRB2 (0.47) | PARP1LMNAGAASNCANAMPT | |
| SCHEMBL13840701 | 0.85 | PARP1 (0.44) | PARP1LMNAGAAOPRM1OPRD1 | |
| SCHEMBL3924678 | 0.85 | PARP1 (0.44) | PARP1LMNAGAAOPRM1OPRD1 | |
| SCHEMBL13840617 | 0.84 | ADRB2 (0.47) | RAB9AADRB2ADRB1 | |
| SCHEMBL3913906 | 0.84 | ADRB2 (0.47) | RAB9AADRB2ADRB1 | |
| SCHEMBL13840627 | 0.84 | ADRB2 (0.39) | ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7538141-B2 | Compounds for the treatment of diseases | PFIZER INC. | 2009-05-26 | — | — | US | disclosed |