Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 9/20 | 0.42 |
| ▸ | SNCA | P37840 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3924678 | 1.00 | PARP1 (0.44) | PARP1LMNAADRB1OPRM1OPRD1 | |
| SCHEMBL13840708 | 0.88 | ADRB2 (0.45) | ADRB1ADRB2SNCA | |
| SCHEMBL3918580 | 0.88 | ADRB2 (0.45) | ADRB1ADRB2SNCA | |
| SCHEMBL3917066 | 0.87 | NPC1 (0.47) | PARP1ADRB1ADRB2GAANPC1 | |
| SCHEMBL13840696 | 0.87 | NPC1 (0.47) | PARP1ADRB1ADRB2GAANPC1 | |
| SCHEMBL4395165 | 0.86 | ADRB2 (0.61) | ADRB1ADRB2TSHRHIF1A | |
| SCHEMBL4395162 | 0.86 | ADRB2 (0.61) | ADRB1ADRB2TSHRHIF1A | |
| SCHEMBL13840626 | 0.85 | PARP1 (0.41) | PARP1LMNAADRB1OPRM1OPRD1 | |
| SCHEMBL3925046 | 0.85 | PARP1 (0.41) | PARP1LMNAADRB1OPRM1OPRD1 | |
| SCHEMBL3916802 | 0.84 | ADRB2 (0.43) | PARP1LMNAADRB1ADRB2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7538141-B2 | Compounds for the treatment of diseases | PFIZER INC. | 2009-05-26 | — | — | US | disclosed |
| US-7538141-B2 | Compounds for the treatment of diseases | PFIZER INC. | 2009-05-26 | — | — | US | disclosed |