Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 13/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3914423 | 1.00 | PARP1 (0.46) | PARP1ADRB2HIF1AMAPTADRB1 | |
| SCHEMBL13840708 | 0.90 | ADRB2 (0.45) | ADRB2MAPTADRB1 | |
| SCHEMBL3918580 | 0.90 | ADRB2 (0.45) | ADRB2MAPTADRB1 | |
| SCHEMBL13840707 | 0.88 | ADRB2 (0.43) | PARP1ADRB2HIF1AADRB1 | |
| SCHEMBL3916802 | 0.88 | ADRB2 (0.43) | PARP1ADRB2HIF1AADRB1 | |
| SCHEMBL13840696 | 0.87 | NPC1 (0.47) | PARP1ADRB2MAPTADRB1 | |
| SCHEMBL3917066 | 0.87 | NPC1 (0.47) | PARP1ADRB2MAPTADRB1 | |
| SCHEMBL4391611 | 0.87 | ADRB2 (0.62) | ADRB2HIF1AADRB1 | |
| SCHEMBL4391614 | 0.87 | ADRB2 (0.62) | ADRB2HIF1AADRB1 | |
| SCHEMBL6533992 | 0.85 | ADRB2 (0.49) | PARP1ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730141-B1 | COMPOUNDS FOR THE TREATMENT OF DISEASES | PFIZER LTD (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-7538141-B2 | Compounds for the treatment of diseases | PFIZER INC. | 2009-05-26 | — | — | US | disclosed |
| US-7538141-B2 | Compounds for the treatment of diseases | PFIZER INC. | 2009-05-26 | — | — | US | disclosed |