Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 12/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3924003 | 1.00 | ADRB2 (0.49) | ADRB2RAB9ASMN1; SMN2NPC1HTT | |
| SCHEMBL3917066 | 0.92 | NPC1 (0.47) | ADRB2RAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL13840696 | 0.92 | NPC1 (0.47) | ADRB2RAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL3915709 | 0.91 | ADRB2 (0.57) | ADRB2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL13840709 | 0.91 | ADRB2 (0.57) | ADRB2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL13840714 | 0.87 | ADRB2 (0.65) | ADRB2RAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL3914436 | 0.87 | ADRB2 (0.65) | ADRB2RAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL4393362 | 0.87 | ADRB2 (0.67) | ADRB2CYP1A2ADRB1 | |
| SCHEMBL4393355 | 0.87 | ADRB2 (0.67) | ADRB2CYP1A2ADRB1 | |
| SCHEMBL6253310 | 0.83 | ADRB2 (0.46) | ADRB2RAB9ASMN1; SMN2NPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7538141-B2 | Compounds for the treatment of diseases | PFIZER INC. | 2009-05-26 | — | — | US | disclosed |
| US-7538141-B2 | Compounds for the treatment of diseases | PFIZER INC. | 2009-05-26 | — | — | US | disclosed |