Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.55 |
| ▸ | HTR3B | O95264 | 3/20 | 0.55 |
| ▸ | HTR3A | P46098 | 3/20 | 0.55 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.55 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17025733 | 0.77 | HTR3E (0.82) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL3301477 | 0.75 | IKBKB (0.47) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL2078783 | 0.74 | HTR3E (0.78) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL2079279 | 0.73 | HTR3E (0.76) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL1019079 | 0.71 | MEN1 (0.60) | KMT2AMEN1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL16913002 | 0.71 | MEN1 (0.60) | KMT2AMEN1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL13844901 | 0.71 | ALDH1A1 (0.77) | KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL18324710 | 0.69 | KDM4E (0.57) | KMT2AALDH1A1GAA | |
| SCHEMBL15246477 | 0.69 | ALDH1A1 (0.60) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL1870212 | 0.69 | ALDH1A1 (0.51) | KMT2AMEN1ALDH1A1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009056693-A1 | NOVEL DERIVATIVES OF N, N'- 2, 4-DIANILINOPYRIMIDINES, PREPARATION THEREOF AS MEDICAMENTS PHARMACEUTICAL COMPOSITIONS AND IN PARTICULAR AS IKK INHIBITORS | SANOFI-AVENTIS (FR) | 2009-05-07 | — | — | WO | disclosed |