Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.41 |
| ▸ | SOD1 | P00441 | 1/20 | 0.40 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3844908 | 0.74 | PRKCQ (0.42) | PRKCQEGFRCSNK2A1TYRO3HDAC3 | |
| SCHEMBL13608180 | 0.73 | MKNK1 (0.43) | MKNK1MKNK2LMNACYP1A2CYP3A4 | |
| SCHEMBL4038322 | 0.68 | FGFR1 (0.59) | MKNK1MKNK2EGFRAURKAPAK4 | |
| SCHEMBL16797122 | 0.68 | CD38 (0.40) | CYP3A4PRKCQHDAC3ABL1 | |
| SCHEMBL3189638 | 0.66 | STAT6 (0.39) | CYP1A2CYP2D6CYP2C9CYP2C19CLK4 | |
| SCHEMBL1184674 | 0.65 | PLK1 (0.59) | — | |
| SCHEMBL18918993 | 0.65 | DHFR (0.43) | PRKCQHDAC3 | |
| SCHEMBL30850536 | 0.64 | LMNA (0.47) | LMNACYP1A2CYP2D6HDAC3AURKA | |
| SCHEMBL4922311 | 0.64 | LMNA (0.47) | LMNACYP1A2CYP2D6HDAC3AURKA | |
| SCHEMBL18803628 | 0.63 | MKNK2 (1.00) | MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009062059-A2 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2009-05-14 | — | — | WO | disclosed |