Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 11/20 | 0.59 |
| ▸ | IGF1R | P08069 | 10/20 | 0.59 |
| ▸ | KDR | P35968 | 10/20 | 0.59 |
| ▸ | INSR | P06213 | 3/20 | 0.53 |
| ▸ | JAK2 | O60674 | 3/20 | 0.52 |
| ▸ | AURKA | O14965 | 2/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.52 |
| ▸ | JAK3 | P52333 | 2/20 | 0.52 |
| ▸ | PLK4 | O00444 | 2/20 | 0.52 |
| ▸ | PAK4 | O96013 | 2/20 | 0.52 |
| ▸ | STK10 | O94804 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | FER | P16591 | 1/20 | 0.52 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.52 |
| ▸ | TYK2 | P29597 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.52 |
| ▸ | STAT5A | P42229 | 1/20 | 0.52 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2120422 | 0.81 | IGF1R (0.64) | FGFR1IGF1RKDRINSRJAK2 | |
| SCHEMBL4034569 | 0.77 | IGF1R (0.66) | FGFR1IGF1RKDRINSRJAK2 | |
| SCHEMBL2121130 | 0.74 | IGF1R (1.00) | FGFR1IGF1RKDRINSRJAK2 | |
| SCHEMBL218642 | 0.74 | MEN1 (0.62) | FGFR1IGF1RKDRINSRJAK2 | |
| SCHEMBL4005596 | 0.71 | MEN1 (0.59) | FGFR1IGF1RKDRINSRJAK2 | |
| SCHEMBL2123793 | 0.71 | IGF1R (0.78) | FGFR1IGF1RKDRINSRJAK2 | |
| SCHEMBL4036060 | 0.71 | IGF1R (0.55) | FGFR1IGF1RKDRINSRJAK2 | |
| SCHEMBL3338201 | 0.71 | NTRK1 (0.59) | FGFR1IGF1RKDRINSRJAK2 | |
| SCHEMBL18853845 | 0.70 | JAK2 (0.84) | FGFR1IGF1RKDRJAK2AURKA | |
| SCHEMBL2121059 | 0.69 | IGF1R (0.81) | FGFR1IGF1RKDRINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456182-B1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF INSULINE-LIKE GROWTH FACTOR-1 RECEPTOR (IGF-I) | ASTRAZENECA AB (SE) | 2009-03-11 | — | — | EP | disclosed |