Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 8/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13845154 | 0.90 | PRKCQ (0.46) | PRKCQ | |
| SCHEMBL13845160 | 0.88 | KDM1A (0.41) | PRKCQCHEK1KDM1ABRD4ATAD2 | |
| SCHEMBL13845148 | 0.82 | HRH3 (0.38) | BRD4 | |
| SCHEMBL13845141 | 0.76 | GBA1 (0.34) | PRKCQ | |
| SCHEMBL13845174 | 0.74 | PRKCQ (0.48) | PRKCQCHEK1KDM1ABRD4ATAD2 | |
| SCHEMBL13845246 | 0.73 | TYRO3 (0.42) | PRKCQ | |
| SCHEMBL13608514 | 0.72 | KDM1A (0.38) | SYKCHEK1KDM1ABRD4ATAD2 | |
| SCHEMBL13608390 | 0.71 | JAK2 (0.43) | SYKCHEK1BRD4ATAD2AURKB | |
| SCHEMBL13608437 | 0.71 | JAK2 (0.43) | SYKCHEK1BRD4ATAD2AURKB | |
| SCHEMBL13845177 | 0.69 | PRKCQ (0.51) | PRKCQCHEK1KDM1ABRD4ATAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009062059-A2 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2009-05-14 | — | — | WO | disclosed |