Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 3/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.37 |
| ▸ | MERTK | Q12866 | 3/20 | 0.37 |
| ▸ | GAS6 | Q14393 | 3/20 | 0.37 |
| ▸ | AXL | P30530 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 3/20 | 0.36 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13845192 | 0.88 | PRKCQ (0.44) | KDM1APRKCQCHEK1BRD4ATAD2 | |
| SCHEMBL13845154 | 0.86 | PRKCQ (0.46) | PRKCQROCK1FLT3TYRO3MERTK | |
| SCHEMBL13845174 | 0.77 | PRKCQ (0.48) | KDM1APRKCQFLT3TYRO3MERTK | |
| SCHEMBL13845141 | 0.76 | GBA1 (0.34) | PRKCQGBA1 | |
| SCHEMBL13845177 | 0.71 | PRKCQ (0.51) | KDM1APRKCQFLT3TYRO3MERTK | |
| SCHEMBL13845148 | 0.71 | HRH3 (0.38) | MERTKBRD4 | |
| SCHEMBL13608426 | 0.70 | JAK2 (0.42) | KDM1APRKCQCYP3A4CYP2C9BRD4 | |
| SCHEMBL13608448 | 0.70 | JAK2 (0.42) | KDM1APRKCQCYP3A4CYP2C9BRD4 | |
| SCHEMBL13845246 | 0.70 | TYRO3 (0.42) | PRKCQFLT3TYRO3MERTKGAS6 | |
| SCHEMBL14391028 | 0.67 | TYRO3 (0.54) | PRKCQFLT3TYRO3MERTKGAS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009062059-A2 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2009-05-14 | — | — | WO | disclosed |