Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 5/20 | 0.37 |
| ▸ | JAK3 | P52333 | 5/20 | 0.37 |
| ▸ | JAK1 | P23458 | 4/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.36 |
| ▸ | SMOX | Q9NWM0 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13845176 | 0.80 | JAK2 (0.44) | CSF1RJAK2JAK3JAK1LMNA | |
| SCHEMBL19929868 | 0.69 | JAK2 (0.43) | MEN1KMT2AJAK2BCHEACHE | |
| SCHEMBL22754163 | 0.68 | EIF2AK1 (0.38) | CSF1RMEN1KMT2ABCHEACHE | |
| SCHEMBL11148663 | 0.64 | MAPT (0.46) | MEN1KMT2AJAK2JAK3JAK1 | |
| SCHEMBL11291747 | 0.64 | CD38 (0.47) | MEN1KMT2AJAK2JAK3JAK1 | |
| SCHEMBL19929931 | 0.63 | LMNA (0.38) | CSF1RJAK2JAK3JAK1LMNA | |
| SCHEMBL28137002 | 0.62 | CSF1R (0.49) | CSF1RHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL12651376 | 0.62 | LRRK2 (0.38) | JAK2 | |
| SCHEMBL15553220 | 0.61 | CSF1R (0.57) | CSF1RMEN1KMT2AJAK2JAK3 | |
| SCHEMBL9232504 | 0.61 | KMT2A (0.41) | MEN1KMT2ALMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009062059-A2 | ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS | PHARMACOPEIA, INC. (US) | 2009-05-14 | — | — | WO | disclosed |