Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 3/20 | 0.42 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | BTK | Q06187 | 2/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | EIF2AK1 | Q9BQI3 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.35 |
| ▸ | TCF7L2 | Q9NQB0 | 4/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22754157 | 0.84 | JAK2 (0.46) | JAK2PIP4K2CLCKBTKAHR | |
| SCHEMBL18194313 | 0.82 | JAK2 (0.45) | JAK2PIP4K2CAHRAPP | |
| SCHEMBL19929876 | 0.76 | BCHE (0.41) | BCHEACHEPIP4K2CMEN1KMT2A | |
| SCHEMBL19930116 | 0.74 | PIP4K2C (0.41) | BCHEACHEPIP4K2CCTNNB1TCF7L2 | |
| SCHEMBL19921101 | 0.71 | ALK (0.58) | JAK2BTK | |
| SCHEMBL22754163 | 0.70 | EIF2AK1 (0.38) | BCHEACHELCKBTKEIF2AK1 | |
| SCHEMBL13845183 | 0.69 | CSF1R (0.41) | JAK2BCHEACHELCKBTK | |
| SCHEMBL13845176 | 0.68 | JAK2 (0.44) | JAK2CTNNB1TCF7L2 | |
| SCHEMBL19929908 | 0.67 | ALK (0.36) | BCHEACHEAPP | |
| SCHEMBL18194341 | 0.67 | XDH (0.51) | AHRAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290420-B1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | UNIV XIAMEN (CN) | 2020-12-09 | — | — | EP | disclosed |
| EP-3290420-A1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | Xiamen University (CN) | 2018-03-07 | — | — | EP | disclosed |