Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.71 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL508185 | 0.84 | ALOX15 (0.98) | ALOX15CHRM1CHRM4CHRM2CHRM5 | |
| SCHEMBL29468680 | 0.84 | ALOX15 (0.98) | ALOX15CHRM1CHRM4CHRM2CHRM5 | |
| SCHEMBL29462345 | 0.84 | ALOX15 (0.98) | ALOX15CHRM1CHRM4CHRM2CHRM5 | |
| SCHEMBL508184 | 0.84 | ALOX15 (0.98) | ALOX15CHRM1CHRM4CHRM2CHRM5 | |
| SCHEMBL2824864 | 0.68 | BRD4 (0.56) | ALOX15BRD4CREBBPMEN1KMT2A | |
| SCHEMBL9202802 | 0.64 | ALOX15 (0.53) | ALOX15BRD4CREBBP | |
| SCHEMBL9198302 | 0.61 | ALOX15 (0.50) | ALOX15BRD4CREBBPCHRM1CHRM4 | |
| SCHEMBL2212650 | 0.60 | CHRM4 (0.50) | ALOX15CHRM1CHRM4 | |
| SCHEMBL22716676 | 0.60 | MAPK1 (0.55) | ALOX15BRD4CREBBPCHRM1CHRM4 | |
| SCHEMBL28355036 | 0.60 | BRD4 (0.61) | ALOX15BRD4CREBBPBLMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009060203-A1 | 3,4,6,7-TETRAHYDRO-1 H-PYRROLO[3,4-D]PYRIMIDINE-2,5-DIONES AND THEIR THERAPEUTIC USE | ARGENTA DISCOVERY LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |