Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | GUSB | P08236 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5128481 | 0.82 | TSHR (0.45) | HTTTSHRLMNAKDM4ENPC1 | |
| SCHEMBL5128474 | 0.81 | TSHR (0.44) | HTTTSHRLMNAKDM4ENPC1 | |
| SCHEMBL14306234 | 0.81 | TSHR (0.57) | HTTTSHRLMNAKDM4ENCF1 | |
| SCHEMBL13845816 | 0.79 | L3MBTL1 (0.54) | HTTTSHRLMNAKDM4ENPC1 | |
| SCHEMBL14320172 | 0.78 | UTS2R (0.44) | HTTTSHRLMNAKDM4ETP53 | |
| SCHEMBL14313669 | 0.76 | LMNA (0.47) | HTTTSHRLMNATP53POLB | |
| SCHEMBL4832560 | 0.75 | TSHR (0.55) | HTTTSHRLMNAKDM4ENPC1 | |
| SCHEMBL3977889 | 0.75 | TSHR (0.52) | HTTTSHRLMNAKDM4ENPC1 | |
| SCHEMBL3976760 | 0.75 | TSHR (0.52) | HTTTSHRLMNAKDM4ENPC1 | |
| SCHEMBL3992613 | 0.75 | TSHR (0.52) | HTTTSHRLMNAKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009063364-A2 | MODULATORS OF UROTENSIN RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS INC. (US) | 2009-05-22 | — | — | WO | disclosed |