Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ACLY | P53396 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609492 | 0.89 | ACLY (0.49) | MAPTALDH1A1ATMHPGDPOLB | |
| SCHEMBL8211774 | 0.87 | HRH4 (0.49) | MAPTALDH1A1ATMHPGDPOLB | |
| SCHEMBL8169729 | 0.87 | ACLY (0.48) | MAPTALDH1A1ATMHPGDPOLB | |
| SCHEMBL15652281 | 0.87 | ALDH1A1 (0.56) | MAPTALDH1A1ATMHPGDPOLB | |
| SCHEMBL3595986 | 0.84 | TACR1 (0.50) | MAPTALDH1A1ATMHPGDPOLB | |
| SCHEMBL5190700 | 0.84 | ACLY (0.48) | MAPTALDH1A1ATMHPGDPOLB | |
| SCHEMBL3592777 | 0.84 | TACR1 (0.50) | MAPTALDH1A1ATMHPGDPOLB | |
| SCHEMBL3582974 | 0.81 | ACLY (0.49) | MAPTALDH1A1HPGDPOLBACLY | |
| SCHEMBL5192240 | 0.79 | LTA4H (0.64) | MAPTALDH1A1HPGDLMNATP53 | |
| SCHEMBL13846213 | 0.77 | MAPK1 (0.61) | MAPTALDH1A1HPGDPOLBACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009063365-A1 | AZETIDINES AS EP2 ANTAGONISTS | PFIZER LIMITED (GB) | 2009-05-22 | — | — | WO | disclosed |