Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15650550 | 0.85 | ALDH1A1 (0.48) | LRRK2NPC1RAB9AHRH4KDM2B | |
| SCHEMBL8212475 | 0.85 | ESR2 (0.43) | LRRK2NPC1RAB9AKDM2BKDM4C | |
| SCHEMBL13729002 | 0.85 | KDM2B (0.41) | LRRK2NPC1RAB9AKDM2BKDM4C | |
| SCHEMBL13838574 | 0.82 | KDM2B (0.42) | LRRK2NPC1RAB9AHRH4KDM2B | |
| SCHEMBL8211774 | 0.82 | HRH4 (0.49) | LRRK2HRH4MAPTMEN1KMT2A | |
| SCHEMBL2228882 | 0.82 | KMO (0.64) | LRRK2KDM2BKDM4CHSD11B1KMO | |
| SCHEMBL5064586 | 0.80 | XDH (0.49) | LRRK2NPC1RAB9AKDM2BKDM4C | |
| SCHEMBL5058907 | 0.80 | ALDH1A1 (0.42) | LRRK2NPC1RAB9AKDM2BKDM4C | |
| SCHEMBL2611134 | 0.79 | KMT2A (0.54) | NPC1RAB9AMGLLMAPTMEN1 | |
| SCHEMBL8205448 | 0.77 | XPO1 (0.48) | NPC1RAB9AHRH4KDM2BKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009063365-A1 | AZETIDINES AS EP2 ANTAGONISTS | PFIZER LIMITED (GB) | 2009-05-22 | — | — | WO | disclosed |