Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 9/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.46 |
| ▸ | AHR | P35869 | 2/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21366239 | 0.88 | MAPT (0.63) | MAPTCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL22462565 | 0.80 | MEN1 (0.77) | PKMMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5216804 | 0.79 | MAPT (0.67) | PKMMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10918829 | 0.78 | HDAC1 (0.60) | MAPTNPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL5125370 | 0.74 | RAB9A (0.49) | PKMMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4722943 | 0.74 | MAPT (0.52) | PKMMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1246735 | 0.73 | RAB9A (0.64) | PKMMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21366323 | 0.72 | GPR84 (0.54) | MAPTCYP3A4CYP2C19CYP2D6MEN1 | |
| SCHEMBL2838509 | 0.72 | RAB9A (0.62) | PKMMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2838513 | 0.72 | RAB9A (0.62) | PKMMAPTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1365760-B1 | PREPARATIONS AND USE OF AN AH RECEPTOR LIGAND, 2-(1'H-INDOLE-3'-CARBONYL)-THIAZOLE-4-CARBOXYLIC ACID METHYL ESTER | WISCONSIN ALUMNI RES FOUND (US) | 2009-05-20 | — | — | EP | disclosed |