Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | RGS4 | P49798 | 1/20 | 0.36 |
| ▸ | RGS8 | P57771 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24801722 | 0.85 | P2RX7 (0.39) | ALOX15HSD17B10P2RX7NPC1MEN1 | |
| SCHEMBL20793140 | 0.83 | P2RX7 (0.40) | ALOX15HSD17B10P2RX7NPC1MEN1 | |
| SCHEMBL7896130 | 0.82 | POLB (0.44) | P2RX7NPC1MEN1KMT2ARECQL | |
| SCHEMBL20793372 | 0.80 | P2RX7 (0.41) | ALOX15HSD17B10P2RX7NPC1MEN1 | |
| SCHEMBL9848826 | 0.79 | P2RX7 (0.39) | ALOX15HSD17B10P2RX7NPC1RAB9A | |
| SCHEMBL23875186 | 0.79 | ALOX15 (0.38) | ALOX15NPC1MEN1KMT2ARECQL | |
| SCHEMBL24801766 | 0.79 | KMT2A (0.41) | NPC1MEN1KMT2ARECQLSLC6A2 | |
| SCHEMBL14447389 | 0.77 | MCHR1 (0.43) | NPC1RAB9APOLB | |
| SCHEMBL12706449 | 0.77 | P2RX7 (0.40) | ALOX15HSD17B10P2RX7NPC1SLC6A2 | |
| SCHEMBL14094400 | 0.77 | ALDH1A1 (0.42) | ALOX15HSD17B10P2RX7PARP1RGS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022269508-A1 | PYRAZOLYL DERIVATIVES AS INHIBITORS OF THE KRAS MUTANT PROTEIN | NOVARTIS AG (CH) | 2022-12-29 | — | — | WO | disclosed |
| WO-2019046150-A1 | MACROCYCLIC COMPOUNDS THAT INHIBIT MCL-1 PROTEIN | AMGEN INC. (US) | 2019-03-07 | — | — | WO | disclosed |
| US-20090131436-A1 | Pyrimidine Derivatives | NOVARTIS AG (CH) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131436-A1 | Pyrimidine Derivatives | DPYD, TYMP, TYMS | ALOX15 2813/4885HSD17B10 2265/4885P2RX7 149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.