Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.56 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | CFTR | P13569 | 5/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | IDE | P14735 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14398035 | 0.87 | BAZ2B (0.60) | SMN1; SMN2BAZ2BKDRKDM4EMAPT | |
| SCHEMBL12868564 | 0.86 | LMNA (0.78) | LMNASMN1; SMN2PABPC1ATMBAZ2B | |
| SCHEMBL13852792 | 0.81 | BAZ2B (0.48) | LMNASMN1; SMN2PABPC1ATMBAZ2B | |
| SCHEMBL13852919 | 0.80 | CYP1A2 (0.67) | LMNASMN1; SMN2BAZ2BKDRKDM4E | |
| SCHEMBL13852768 | 0.79 | CFTR (0.50) | LMNASMN1; SMN2PABPC1ATMBAZ2B | |
| SCHEMBL602333 | 0.78 | LMNA (0.67) | LMNASMN1; SMN2PABPC1ATMBAZ2B | |
| SCHEMBL7851175 | 0.76 | KDM4E (0.52) | LMNASMN1; SMN2BAZ2BKDRKDM4E | |
| SCHEMBL8794276 | 0.75 | KDM4E (0.68) | LMNASMN1; SMN2KDM4EMAPTALOX15 | |
| SCHEMBL407460 | 0.73 | LMNA (1.00) | LMNASMN1; SMN2PABPC1ATMBAZ2B | |
| SCHEMBL6234998 | 0.73 | KDM4E (0.65) | LMNASMN1; SMN2KDM4EMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090131407-A1 | TETRACYCLIC KINASE INHIBITORS | GENENTECH, INC. | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131407-A1 | TETRACYCLIC KINASE INHIBITORS | CNKSR1, MAP3K19, BRAF | LMNA 2299/4885SMN1; SMN2 4062/4885PABPC1 2523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.