Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | IDE | P14735 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13852921 | 0.83 | HSD17B10 (0.51) | CFTRKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL13852783 | 0.79 | LMNA (0.58) | CFTRKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL13852792 | 0.78 | BAZ2B (0.48) | CFTRKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL13852781 | 0.76 | KDM4E (0.53) | CFTRKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL12868564 | 0.75 | LMNA (0.78) | CFTRKDM4EALDH1A1LMNABAZ2B | |
| SCHEMBL7851175 | 0.69 | KDM4E (0.52) | KDM4EALDH1A1LMNAHPGDMAPT | |
| SCHEMBL30741608 | 0.69 | BAZ2B (0.56) | CFTRLMNABAZ2BPABPC1ATM | |
| SCHEMBL14398035 | 0.68 | BAZ2B (0.60) | CFTRKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL11760636 | 0.67 | SMN1; SMN2 (0.80) | CFTRKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL32666147 | 0.67 | KDM4E (0.50) | KDM4EALDH1A1LMNAHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090131407-A1 | TETRACYCLIC KINASE INHIBITORS | GENENTECH, INC. | 2009-05-21 | — | — | US | disclosed |
| WO-2007120333-A2 | TETRACYCLIC KINASE INHIBITORS | GENENTECH, INC. (US) | 2007-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131407-A1 | TETRACYCLIC KINASE INHIBITORS | CNKSR1, MAP3K19, BRAF | CFTR 4250/4885KDM4E 1144/4885ALDH1A1 3634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.