Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | CFTR | P13569 | 9/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13852783 | 0.87 | LMNA (0.58) | BAZ2BKDRCFTRKDM4EALDH1A1 | |
| SCHEMBL29171356 | 0.85 | BAZ2B (0.82) | BAZ2BKDRCFTRCYP1A2SMN1; SMN2 | |
| SCHEMBL13852919 | 0.83 | CYP1A2 (0.67) | BAZ2BKDRKDM4EALDH1A1MAPT | |
| SCHEMBL5372790 | 0.82 | BAZ2B (0.67) | BAZ2BKDRCFTRMAPKAPK2CYP1A2 | |
| SCHEMBL8794276 | 0.79 | KDM4E (0.68) | KDM4EALDH1A1MAPTHPGDMTNR1A | |
| SCHEMBL4142893 | 0.76 | KDM4E (0.69) | KDM4EALDH1A1MAPTHPGDMTNR1A | |
| SCHEMBL6234998 | 0.76 | KDM4E (0.65) | KDM4EALDH1A1MAPTHPGDMTNR1A | |
| SCHEMBL28465408 | 0.75 | BAZ2B (0.67) | BAZ2BKDRCFTRMAPTCYP1A2 | |
| SCHEMBL8036170 | 0.73 | BAZ2B (0.82) | BAZ2BKDRCFTRCYP1A2NFKB1 | |
| SCHEMBL28464447 | 0.73 | BAZ2B (0.64) | BAZ2BKDRCFTRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007120333-A2 | TETRACYCLIC KINASE INHIBITORS | GENENTECH, INC. (US) | 2007-10-25 | — | — | WO | disclosed |