Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12783279 | 0.88 | EPHX2 (0.53) | ALDH1A1TSHRL3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL26363437 | 0.84 | ALDH1A1 (0.42) | ALDH1A1TSHRL3MBTL1HSD17B10EPHX2 | |
| SCHEMBL19872989 | 0.83 | ALDH1A1 (0.72) | ALDH1A1TSHRL3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL885125 | 0.80 | ALDH1A1 (0.62) | ALDH1A1TSHRL3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL8710833 | 0.80 | ALDH1A1 (0.62) | ALDH1A1TSHRL3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL17122158 | 0.79 | TSHR (0.56) | ALDH1A1TSHRL3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL19808633 | 0.78 | ALDH1A1 (0.61) | ALDH1A1TSHRL3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL12543513 | 0.78 | ALDH1A1 (0.61) | ALDH1A1TSHRL3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL2303769 | 0.78 | ALDH1A1 (0.61) | ALDH1A1TSHRL3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL13853550 | 0.78 | TSHR (0.59) | ALDH1A1TSHRSMN1; SMN2LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354418-B2 | Thiazolyl-dihydro-quinazolines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-01-15 | — | — | US | disclosed |
| US-20090131424-A1 | THIAZOLYL-DIHYDRO-CHINAZOLINE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-05-21 | — | — | US | disclosed |
| US-20070238746-A1 | THIAZOLYL-DIHYDRO-CHINAZOLINE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070238746-A1 | THIAZOLYL-DIHYDRO-CHINAZOLINE | CYP3A7, UGT2B7, UGT1A7 | ALDH1A1 165/4885TSHR 210/4885L3MBTL1 4144/4885 |
| US-20090131424-A1 | THIAZOLYL-DIHYDRO-CHINAZOLINE | CYP3A7, UGT2B7, UGT1A7 | ALDH1A1 165/4885TSHR 210/4885L3MBTL1 4144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.