Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 10/20 | 0.65 |
| ▸ | AXL | P30530 | 2/20 | 0.65 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.63 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.63 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.63 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.63 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.61 |
| ▸ | BRD4 | O60885 | 1/20 | 0.57 |
| ▸ | PLK4 | O00444 | 2/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.54 |
| ▸ | INSR | P06213 | 2/20 | 0.54 |
| ▸ | CDK1 | P06493 | 2/20 | 0.54 |
| ▸ | ROS1 | P08922 | 2/20 | 0.54 |
| ▸ | FER | P16591 | 2/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | MARK3 | P27448 | 2/20 | 0.54 |
| ▸ | FLT4 | P35916 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4831501 | 0.87 | CDK8 (0.81) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL3136284 | 0.87 | CDK8 (0.71) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL413503 | 0.86 | RIPK1 (0.71) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL297772 | 0.83 | CDK8 (0.55) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL17854924 | 0.81 | RIPK1 (0.64) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL13854147 | 0.80 | RIPK1 (0.62) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL857265 | 0.80 | RIPK1 (0.57) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL13854134 | 0.79 | CDK8 (0.65) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL13854150 | 0.79 | NUDT1 (0.56) | CDK8AXLPIK3CDPIK3CAPIK3CB | |
| SCHEMBL13854145 | 0.79 | ALOX5AP (0.61) | CDK8AXLPIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7534800-B2 | 7-azaindoles as inhibitors of c-Jun N-terminal kinases for the treatment of neurodegenerative disorders | EISAI R & D DEVELOPMENT CO., LTD. (JP) | 2009-05-19 | — | — | US | disclosed |
| US-7534800-B2 | 7-azaindoles as inhibitors of c-Jun N-terminal kinases for the treatment of neurodegenerative disorders | EISAI R & D DEVELOPMENT CO., LTD. (JP) | 2009-05-19 | — | — | US | disclosed |
| US-7291630-B2 | Azaindoles as inhibitors of c-Jun N-terminal kinases | EISAI CO., LTD. (JP) | 2007-11-06 | — | — | US | disclosed |
| US-7291630-B2 | Azaindoles as inhibitors of c-Jun N-terminal kinases | EISAI CO., LTD. (JP) | 2007-11-06 | — | — | US | disclosed |