Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN22 | Q9Y2R2 | 5/20 | 0.68 |
| ▸ | DUSP3 | P51452 | 4/20 | 0.68 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.68 |
| ▸ | PPM1A | P35813 | 1/20 | 0.68 |
| ▸ | PTPN9 | P43378 | 1/20 | 0.68 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.68 |
| ▸ | PTPN18 | Q99952 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 6/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.63 |
| ▸ | PTGES | O14684 | 1/20 | 0.60 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.58 |
| ▸ | PTPN12 | Q05209 | 2/20 | 0.56 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | BLM | P54132 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13856592 | 0.96 | PTPN22 (0.61) | PTPN22DUSP3PTPN1PPM1APTPN9 | |
| SCHEMBL13856554 | 0.93 | MEN1 (0.66) | PTPN22DUSP3PTPN1PPM1APTPN9 | |
| SCHEMBL13856501 | 0.92 | PTGES (0.68) | PTPN22DUSP3PTPN1PPM1APTPN9 | |
| SCHEMBL2423876 | 0.92 | PTGES (0.61) | PTPN22DUSP3PTPN1PPM1APTPN9 | |
| SCHEMBL2423878 | 0.92 | PTGES (0.61) | PTPN22DUSP3PTPN1PPM1APTPN9 | |
| SCHEMBL13856650 | 0.91 | MEN1 (0.64) | PTPN22DUSP3PTPN1PPM1APTPN9 | |
| SCHEMBL14104273 | 0.89 | PTGES (0.55) | PTPN22DUSP3PTPN1PPM1APTPN9 | |
| SCHEMBL13856499 | 0.88 | PTGES (0.67) | PTPN22DUSP3MEN1KMT2APTGES | |
| SCHEMBL12325905 | 0.87 | NPSR1 (0.69) | PTPN22DUSP3PTPN1PPM1APTPN9 | |
| SCHEMBL13856782 | 0.87 | MEN1 (0.63) | PTPN22DUSP3PTPN1PPM1APTPN9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8436031-B2 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2013-05-07 | — | — | US | disclosed |
| US-20090131401-A1 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2009-05-21 | — | — | US | disclosed |
| US-20090131401-A1 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2009-05-21 | — | — | US | disclosed |
| US-7405235-B2 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2008-07-29 | — | — | US | disclosed |
| US-7405235-B2 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2008-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131401-A1 | Transcription factor modulating compounds and methods of use thereof | JUN, CREBBP, TFEB | PTPN22 4669/4885DUSP3 2523/4885PTPN1 4764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.