Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 10/20 | 0.44 |
| ▸ | LDHB | P07195 | 9/20 | 0.44 |
| ▸ | ALB | P02768 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | VCP | P55072 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1144495 | 0.83 | ALB (0.31) | LDHALDHBALBKDM4EMEN1 | |
| Gossypolone SCHEMBL29407306 | 0.76 | AKR1B1 (0.44) | LDHALDHBALBKDM4EMEN1 | |
| Gossypolone SCHEMBL2622243 | 0.76 | AKR1B1 (0.44) | LDHALDHBALBKDM4EMEN1 | |
| SCHEMBL1144454 | 0.73 | AKR1B1 (0.33) | — | |
| SCHEMBL12856168 | 0.71 | — | — | |
| SCHEMBL1143986 | 0.69 | — | — | |
| SCHEMBL13857056 | 0.69 | ALDH1A1 (0.33) | ALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL22700493 | 0.68 | AKR1B1 (0.38) | LDHALDHBALBKDM4EMEN1 | |
| SCHEMBL1890983 | 0.68 | EGFR (0.42) | ALBKDM4EMEN1NPC1USP2 | |
| SCHEMBL12856175 | 0.67 | TYR (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118377-A1 | APOGOSSYPOLONE AND THE USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-05-07 | — | — | US | disclosed |
| US-20090118377-A1 | APOGOSSYPOLONE AND THE USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118377-A1 | APOGOSSYPOLONE AND THE USES THEREOF | BCL2, BAD, BAX | LDHA 4346/4885LDHB 3645/4885ALB 4294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.