Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 5/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.44 |
| ▸ | BCL2 | P10415 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gossypolone SCHEMBL29407306 | 1.00 | AKR1B1 (0.44) | AKR1B1MCL1BCL2KDM4EMEN1 | |
| SCHEMBL22700493 | 0.89 | AKR1B1 (0.38) | AKR1B1MCL1BCL2KDM4EMEN1 | |
| SCHEMBL22686504 | 0.87 | ALB (0.42) | AKR1B1MCL1BCL2KDM4EMEN1 | |
| SCHEMBL1144495 | 0.82 | ALB (0.31) | AKR1B1MCL1BCL2KDM4EMEN1 | |
| SCHEMBL22700684 | 0.81 | MCL1 (0.39) | AKR1B1MCL1BCL2KDM4EMEN1 | |
| SCHEMBL22700393 | 0.81 | ALB (0.37) | AKR1B1MCL1BCL2KDM4EMEN1 | |
| SCHEMBL22700711 | 0.79 | MCL1 (0.38) | AKR1B1MCL1BCL2KDM4EMEN1 | |
| SCHEMBL22700387 | 0.79 | AKR1B1 (0.37) | AKR1B1MCL1BCL2KDM4EMEN1 | |
| SCHEMBL22700777 | 0.78 | ALDH1A1 (0.40) | AKR1B1MCL1BCL2KDM4EMEN1 | |
| SCHEMBL22700754 | 0.77 | ALB (0.34) | AKR1B1MCL1BCL2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210379078-A1 | Killing Senescent Cells And Treating Senescence-Associated Conditions Using A Bcl Inhibitor And An Mcl-1 Inhibitor | UNITY BIOTECHNOLOGY, INC. | 2021-12-09 | — | — | US | disclosed |
| US-20200369618-A1 | ASYMMETRIC DERIVATIVES OF POLYPHENOLS OF THE DINAPHTHALINE SERIES, PROCESS OF PREPARING AND USE THEREOF | Nearmedic International Limited (CY) | 2020-11-26 | — | — | US | disclosed |
| US-8163805-B2 | Small molecule antagonists of Bcl-2 family proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163805-B2 | Small molecule antagonists of Bcl-2 family proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-04-24 | — | — | US | disclosed |
| US-20110046233-A1 | GOSSYPOL DERIVATIVES, PRODUCTION METHOD THEREOF AND USES OF SAME | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-02-24 | — | — | US | disclosed |
| US-7851510-B2 | protein kinase inhibitors such as 6,7,6',7'-tetrahydroxy-8,8'-bis-methoxymethyl-5,5'-diisopropyl-3,3'-dimethyl-[2,2']binaphthalenyl-1,4,1',4'-tetraone, used in the treatment of melanomas, glioblastomas, adenocarcinomas, colon, lung, prostate or breast cancers | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2010-12-14 | — | — | US | disclosed |
| EP-1474121-B1 | Synergistic association of (-)- gossypol with docetaxel or paclitaxel for cancer treatment | UNIV MICHIGAN (US) | 2010-07-21 | — | — | EP | disclosed |
| US-20100069344-A1 | SMALL MOLECULE ANTAGONISTS OF BCL2 FAMILY PROTEINS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-03-18 | — | — | US | disclosed |
| US-20100069344-A1 | SMALL MOLECULE ANTAGONISTS OF BCL2 FAMILY PROTEINS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-03-18 | — | — | US | disclosed |
| US-20090318566-A1 | GOSSYPOL DERIVATIVES, PRODUCTION METHOD THEREOF AND USES OF SAME | MICHELOT, ROBERT, MR. (FR) | 2009-12-24 | — | — | US | disclosed |
| US-20090092684-A1 | SMALL MOLECULE ANTAGONISTS OF BCL-2 FAMILY PROTEINS | GEORGETOWN UNIVERSITY | 2009-04-09 | — | — | US | disclosed |
| US-20090092684-A1 | SMALL MOLECULE ANTAGONISTS OF BCL-2 FAMILY PROTEINS | GEORGETOWN UNIVERSITY | 2009-04-09 | — | — | US | disclosed |
| US-20090082424-A1 | SMALL MOLECULE ANTAGONISTS OF BCL-2 FAMILY PROTEINS | REGENTS OF THE UNIVERSITY OF MICHIGAN, THE | 2009-03-26 | — | — | US | disclosed |
| US-20090082424-A1 | SMALL MOLECULE ANTAGONISTS OF BCL-2 FAMILY PROTEINS | REGENTS OF THE UNIVERSITY OF MICHIGAN, THE | 2009-03-26 | — | — | US | disclosed |
| US-7432304-B2 | Small molecule antagonists of Bcl-2 family proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-10-07 | — | — | US | disclosed |
| US-7432304-B2 | Small molecule antagonists of Bcl-2 family proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-10-07 | — | — | US | disclosed |
| EP-1704136-B1 | GOSSYPOL DERIVATIVES, PRODUCTION METHOD THEREOF AND USES OF SAME | CENTRE NAT RECH SCIENT (FR) | 2008-08-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046233-A1 | GOSSYPOL DERIVATIVES, PRODUCTION METHOD THEREOF AND USES OF SAME | GGPS1, CYP11B1, CYP11B2 | AKR1B1 67/4885MCL1 1753/4885BCL2 764/4885 |
| US-20200369618-A1 | ASYMMETRIC DERIVATIVES OF POLYPHENOLS OF THE DINAPHTHALINE SERIES, PROCESS OF PREPARING AND USE THEREOF | DNM2, DNM1, MAVS | AKR1B1 1151/4885MCL1 3671/4885BCL2 3675/4885 |
| US-20210379078-A1 | Killing Senescent Cells And Treating Senescence-Associated Conditions Using A Bcl Inhibitor And An Mcl-1 Inhibitor | MCL1, BCL2, BCL2L1 | AKR1B1 2967/4885MCL1 1/4885BCL2 2/4885 |
| US-20090092684-A1 | SMALL MOLECULE ANTAGONISTS OF BCL-2 FAMILY PROTEINS | BCL2, BCL2L1, BCL2L2 | AKR1B1 1880/4885MCL1 34/4885BCL2 1/4885 |
| US-20090318566-A1 | GOSSYPOL DERIVATIVES, PRODUCTION METHOD THEREOF AND USES OF SAME | GGPS1, CYP11B1, CYP11B2 | AKR1B1 67/4885MCL1 1753/4885BCL2 764/4885 |
| US-20100069344-A1 | SMALL MOLECULE ANTAGONISTS OF BCL2 FAMILY PROTEINS | BCL2L1, BCL2, BCL2L11 | AKR1B1 1397/4885MCL1 45/4885BCL2 2/4885 |
| US-20090082424-A1 | SMALL MOLECULE ANTAGONISTS OF BCL-2 FAMILY PROTEINS | BCL2, BCL2L1, BCL2L2 | AKR1B1 1880/4885MCL1 34/4885BCL2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.