Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALB | P02768 | 1/20 | 0.31 |
| ▸ | LDHA | P00338 | 2/20 | 0.31 |
| ▸ | LDHB | P07195 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | BCL2 | P10415 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13857053 | 0.83 | LDHA (0.44) | ALBLDHALDHBKDM4EMEN1 | |
| Gossypolone SCHEMBL29407306 | 0.82 | AKR1B1 (0.44) | ALBLDHALDHBKDM4EMEN1 | |
| Gossypolone SCHEMBL2622243 | 0.82 | AKR1B1 (0.44) | ALBLDHALDHBKDM4EMEN1 | |
| SCHEMBL1144454 | 0.78 | AKR1B1 (0.33) | AKR1B1 | |
| SCHEMBL12856168 | 0.76 | — | — | |
| SCHEMBL1143986 | 0.74 | — | — | |
| SCHEMBL22700493 | 0.73 | AKR1B1 (0.38) | ALBLDHALDHBKDM4EMEN1 | |
| SCHEMBL1890983 | 0.73 | EGFR (0.42) | ALBKDM4EMEN1NPC1USP2 | |
| SCHEMBL12856175 | 0.72 | TYR (0.32) | — | |
| SCHEMBL12856269 | 0.72 | AKR1B1 (0.32) | AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110046233-A1 | GOSSYPOL DERIVATIVES, PRODUCTION METHOD THEREOF AND USES OF SAME | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-02-24 | — | — | US | disclosed |
| US-20110046233-A1 | GOSSYPOL DERIVATIVES, PRODUCTION METHOD THEREOF AND USES OF SAME | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-02-24 | — | — | US | disclosed |
| US-20110046233-A1 | GOSSYPOL DERIVATIVES, PRODUCTION METHOD THEREOF AND USES OF SAME | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-02-24 | — | — | US | disclosed |
| US-7851510-B2 | protein kinase inhibitors such as 6,7,6',7'-tetrahydroxy-8,8'-bis-methoxymethyl-5,5'-diisopropyl-3,3'-dimethyl-[2,2']binaphthalenyl-1,4,1',4'-tetraone, used in the treatment of melanomas, glioblastomas, adenocarcinomas, colon, lung, prostate or breast cancers | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2010-12-14 | — | — | US | disclosed |
| US-7851510-B2 | protein kinase inhibitors such as 6,7,6',7'-tetrahydroxy-8,8'-bis-methoxymethyl-5,5'-diisopropyl-3,3'-dimethyl-[2,2']binaphthalenyl-1,4,1',4'-tetraone, used in the treatment of melanomas, glioblastomas, adenocarcinomas, colon, lung, prostate or breast cancers | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2010-12-14 | — | — | US | disclosed |
| US-7851510-B2 | protein kinase inhibitors such as 6,7,6',7'-tetrahydroxy-8,8'-bis-methoxymethyl-5,5'-diisopropyl-3,3'-dimethyl-[2,2']binaphthalenyl-1,4,1',4'-tetraone, used in the treatment of melanomas, glioblastomas, adenocarcinomas, colon, lung, prostate or breast cancers | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2010-12-14 | — | — | US | disclosed |
| US-20090318566-A1 | GOSSYPOL DERIVATIVES, PRODUCTION METHOD THEREOF AND USES OF SAME | MICHELOT, ROBERT, MR. (FR) | 2009-12-24 | — | — | US | disclosed |
| US-20090318566-A1 | GOSSYPOL DERIVATIVES, PRODUCTION METHOD THEREOF AND USES OF SAME | MICHELOT, ROBERT, MR. (FR) | 2009-12-24 | — | — | US | disclosed |
| US-20090318566-A1 | GOSSYPOL DERIVATIVES, PRODUCTION METHOD THEREOF AND USES OF SAME | MICHELOT, ROBERT, MR. (FR) | 2009-12-24 | — | — | US | disclosed |
| EP-1704136-B1 | GOSSYPOL DERIVATIVES, PRODUCTION METHOD THEREOF AND USES OF SAME | CENTRE NAT RECH SCIENT (FR) | 2008-08-13 | — | — | EP | disclosed |
| EP-1697293-B1 | USE OF (Z)-7-CYCLOHEXADECENE-1-ONE AS A PERFUME | SYMRISE GMBH & CO KG (DE) | 2008-08-13 | — | — | EP | disclosed |
| EP-1704136-A1 | GOSSYPOL DERIVATIVES, PRODUCTION METHOD THEREOF AND USES OF SAME | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2006-09-27 | — | — | EP | disclosed |
| WO-2005073158-A1 | GOSSYPOL DERIVATIVES, PRODUCTION METHOD THEREOF AND USES OF SAME | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2005-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046233-A1 | GOSSYPOL DERIVATIVES, PRODUCTION METHOD THEREOF AND USES OF SAME | GGPS1, CYP11B1, CYP11B2 | ALB 4167/4885LDHA 3642/4885LDHB 3540/4885 |
| US-20090318566-A1 | GOSSYPOL DERIVATIVES, PRODUCTION METHOD THEREOF AND USES OF SAME | GGPS1, CYP11B1, CYP11B2 | ALB 4167/4885LDHA 3642/4885LDHB 3540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.