Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.41 |
| ▸ | PIP4K2A | P48426 | 3/20 | 0.41 |
| ▸ | PIP4K2B | P78356 | 3/20 | 0.41 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.39 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12435598 | 0.89 | FADS1 (0.47) | EGFRERBB3MEN1KMT2AMAPT | |
| SCHEMBL13857436 | 0.85 | EGFR (0.42) | EGFRPIP4K2APIP4K2BERBB3MEN1 | |
| SCHEMBL13857439 | 0.84 | GRM4 (0.42) | EGFRPIP4K2APIP4K2BERBB3MEN1 | |
| SCHEMBL13857445 | 0.83 | PIP4K2A (0.44) | EGFRPIP4K2APIP4K2BERBB3MEN1 | |
| SCHEMBL13857438 | 0.80 | BRAF (0.44) | EGFRPIP4K2APIP4K2BERBB3MAPT | |
| SCHEMBL12310571 | 0.79 | GRM5 (0.48) | EGFRPIP4K2APIP4K2BERBB3MEN1 | |
| SCHEMBL12434248 | 0.74 | EGFR (0.46) | EGFRERBB3MEN1KMT2AMAPT | |
| SCHEMBL13857443 | 0.73 | MET (0.47) | EGFRERBB3ERBB4TUBB4ATUBB | |
| SCHEMBL12262295 | 0.72 | MAP3K8 (0.49) | EGFRERBB3MEN1KMT2AMAPT | |
| SCHEMBL12310628 | 0.72 | BACE1 (0.45) | EGFRERBB3ERBB4TUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137588-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137588-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | ABCG2, CYP3A43, CYP3A5 | EGFR 1981/4885PIP4K2A 3115/4885PIP4K2B 2793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.