Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | MET | P08581 | 3/20 | 0.42 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.42 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.42 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | BLK | P51451 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12262294 | 0.88 | L3MBTL1 (0.53) | CCNT1CCNE1CDK2CDK9EGFR | |
| SCHEMBL14773096 | 0.86 | CCNT1 (0.42) | CCNT1CCNE1CDK2CDK9EGFR | |
| SCHEMBL13857436 | 0.85 | EGFR (0.42) | EGFRERBB3PIP4K2APIP4K2BMAPT | |
| SCHEMBL13857445 | 0.85 | PIP4K2A (0.44) | BRAFEGFRERBB3PIP4K2APIP4K2B | |
| SCHEMBL12310571 | 0.82 | GRM5 (0.48) | BRAFEGFRERBB3PIP4K2APIP4K2B | |
| SCHEMBL13857437 | 0.80 | EGFR (0.41) | EGFRERBB3PIP4K2APIP4K2BMAPT | |
| SCHEMBL13857439 | 0.80 | GRM4 (0.42) | EGFRERBB3PIP4K2APIP4K2BMAPT | |
| SCHEMBL13857443 | 0.74 | MET (0.47) | EGFRMETERBB3 | |
| SCHEMBL12310628 | 0.73 | BACE1 (0.45) | BRAFEGFRMETERBB3 | |
| SCHEMBL12434248 | 0.73 | EGFR (0.46) | EGFRERBB3MAPTLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137588-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137588-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | ABCG2, CYP3A43, CYP3A5 | BRAF 2009/4885CCNT1 4285/4885CCNE1 4074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.