Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | CYP2C18 | P33260 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29662378 | 0.79 | POLB (0.47) | POLBCYP2C9HIF1ACYP2C19CYP2C18 | |
| SCHEMBL17902788 | 0.72 | MAPK9 (0.47) | POLBCYP2C9PTGS2LMNACYP3A4 | |
| SCHEMBL27906302 | 0.68 | POLB (0.57) | POLBCYP2C9CYP2C19CYP2C18LMNA | |
| SCHEMBL255499 | 0.68 | POLB (0.57) | POLBCYP2C9CYP2C19CYP2C18LMNA | |
| SCHEMBL8674209 | 0.68 | POLB (0.57) | POLBCYP2C9HIF1ACYP2C19CYP2C18 | |
| SCHEMBL411379 | 0.68 | POLB (0.57) | POLBCYP2C9CYP2C19CYP2C18LMNA | |
| SCHEMBL5318677 | 0.68 | POLB (0.57) | POLBCYP2C9HIF1ACYP2C19CYP2C18 | |
| SCHEMBL5579308 | 0.68 | POLB (0.57) | POLBCYP2C9CYP2C19CYP2C18LMNA | |
| SCHEMBL7082394 | 0.68 | POLB (0.57) | POLBCYP2C9HIF1ACYP2C19CYP2C18 | |
| SCHEMBL17227421 | 0.68 | POLB (0.57) | POLBCYP2C9HIF1ACYP2C19CYP2C18 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108329246-B | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as TRKA kinase inhibitors | 阵列生物制药公司 | 2021-02-26 | — | — | CN | disclosed |
| CN-108329246-A | Pyrrolidinyl urea and pyrrolidinyl thiourea compound as TRKA kinase inhibitors | 阵列生物制药公司 | 2018-07-27 | — | — | CN | disclosed |
| CN-105130967-B | Pyrrolidinyl urea and pyrrolidinyl thiourea compound as TRKA kinase inhibitors | 阵列生物制药公司 | 2018-04-17 | — | — | CN | disclosed |
| WO-2012158413-A2 | PYRROLIDINYL UREA AND PYRROLIDINYL THIOUREA COMPOUNDS AS TRKA KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2012-11-22 | — | — | WO | disclosed |