Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27822210 | 0.78 | OXTR (0.48) | POLBALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL24185602 | 0.78 | NPBWR1 (0.40) | POLBNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2555958 | 0.77 | NPBWR1 (0.45) | POLBALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL10446383 | 0.75 | RAB9A (0.61) | POLBNPC1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL17227421 | 0.73 | POLB (0.57) | POLBNPC1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL411379 | 0.73 | POLB (0.57) | POLBNPC1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL5318677 | 0.73 | POLB (0.57) | POLBNPC1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL255499 | 0.73 | POLB (0.57) | POLBNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8674209 | 0.73 | POLB (0.57) | POLBNPC1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL5579308 | 0.73 | POLB (0.57) | POLBNPC1RAB9ACYP2C9GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104136399-A | Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme | MILLENNIUM PHARM INC | 2014-11-05 | — | — | CN | claimed |
| CN-109662961-A | For improving the method and composition of cognitive function | 约翰斯霍普金斯大学 | 2019-04-23 | — | — | CN | disclosed |
| CN-109662964-A | For improving the method and composition of cognitive function | 约翰斯.霍普金斯大学 | 2019-04-23 | — | — | CN | disclosed |
| CN-104136399-B | The pyrazolopyrimidine base inhibitor of ubiquitin activating enzyme | 米伦纽姆医药公司 | 2018-08-07 | — | — | CN | disclosed |
| CN-105142623-A | Methods and compositions for improving cognitive function | AGENEBIO INC | 2015-12-09 | — | — | CN | disclosed |
| CN-104136399-A | Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme | MILLENNIUM PHARM INC | 2014-11-05 | — | — | CN | disclosed |
| CN-103476255-A | Methods and compositions for improving cognitive function | UNIV JOHNS HOPKINS | 2013-12-25 | — | — | CN | disclosed |
| CN-102905532-A | Methods and compositions for improving cognitive function | UNIV JOHNS HOPKINS | 2013-01-30 | — | — | CN | disclosed |