Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | CYP2C18 | P33260 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL433371 | 0.73 | POLB (1.00) | POLBCYP2C9ALDH1A1NPC1RAB9A | |
| SCHEMBL10280912 | 0.73 | POLB (0.57) | POLBCYP2C9ALDH1A1NPC1RAB9A | |
| SCHEMBL27906302 | 0.73 | POLB (0.57) | POLBCYP2C9ALDH1A1NPC1RAB9A | |
| SCHEMBL17227421 | 0.73 | POLB (0.57) | POLBCYP2C9ALDH1A1NPC1RAB9A | |
| SCHEMBL411379 | 0.73 | POLB (0.57) | POLBCYP2C9ALDH1A1NPC1RAB9A | |
| SCHEMBL5318677 | 0.73 | POLB (0.57) | POLBCYP2C9ALDH1A1NPC1RAB9A | |
| SCHEMBL8674209 | 0.73 | POLB (0.57) | POLBCYP2C9ALDH1A1NPC1RAB9A | |
| SCHEMBL5579308 | 0.73 | POLB (0.57) | POLBCYP2C9NPC1RAB9AKDM4E | |
| SCHEMBL255499 | 0.73 | POLB (0.57) | POLBCYP2C9ALDH1A1NPC1RAB9A | |
| SCHEMBL1155787 | 0.71 | MDM2 (0.55) | POLBCYP2C9ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0680962-B1 | Heterocyclic compounds | ASTRAZENECA AB (SE) | 2003-08-20 | — | — | EP | disclosed |
| US-5739149-A | TREATING ASTHMA | ZENECA LIMITED (GB) | 1998-04-14 | — | — | US | disclosed |
| US-5635509-A | ASTHMA; BRONCHODILATOR AGENTS; VASODILATION MICROVASCULAR PERMEABILITY; MAST CELLS | ZENECA LIMITED (GB) | 1997-06-03 | — | — | US | disclosed |
| EP-0680962-A2 | Heterocyclic compounds | ZENECA LIMITED (GB) | 1995-11-08 | — | — | EP | disclosed |