Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13858646 | 0.89 | ALDH1A1 (0.50) | LMNASMN1; SMN2USP2ALDH1A1RAB9A | |
| SCHEMBL16155973 | 0.89 | LMNA (0.57) | LMNASMN1; SMN2USP2KMT2APOLB | |
| SCHEMBL13720169 | 0.83 | ALDH1A1 (0.48) | LMNASMN1; SMN2USP2ALDH1A1RAB9A | |
| SCHEMBL1790108 | 0.81 | MAPT (0.56) | LMNASMN1; SMN2USP2ALDH1A1RAB9A | |
| SCHEMBL30794643 | 0.81 | MAPT (0.56) | LMNASMN1; SMN2USP2ALDH1A1RAB9A | |
| SCHEMBL13720957 | 0.80 | SMN1; SMN2 (0.47) | LMNASMN1; SMN2USP2ALDH1A1RAB9A | |
| SCHEMBL13721251 | 0.78 | EGFR (0.50) | LMNASMN1; SMN2USP2ALDH1A1RAB9A | |
| SCHEMBL13720474 | 0.77 | KDM4E (0.47) | LMNASMN1; SMN2USP2ALDH1A1RAB9A | |
| SCHEMBL30796305 | 0.77 | TSHR (0.50) | LMNASMN1; SMN2USP2KMT2APOLB | |
| SCHEMBL1791416 | 0.77 | TSHR (0.50) | LMNASMN1; SMN2USP2KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859549-B2 | Potassium channel modulators | ABBVIE, INC. (US) | 2014-10-14 | — | — | US | claimed |
| WO-2012158399-A1 | CONDENSED 2 - CARBAMOYLPYRIDAZINONES AS POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2012-11-22 | — | — | WO | claimed |
| US-8859549-B2 | Potassium channel modulators | ABBVIE, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| WO-2012158399-A1 | CONDENSED 2 - CARBAMOYLPYRIDAZINONES AS POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2012-11-22 | — | — | WO | disclosed |