Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 6/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13858643 | 0.89 | LMNA (0.54) | LMNAPOLBUSP2SMN1; SMN2KMT2A | |
| SCHEMBL13858646 | 0.86 | ALDH1A1 (0.50) | LMNAAKR1B1CNR2USP2SMN1; SMN2 | |
| SCHEMBL30795856 | 0.85 | LMNA (0.52) | LMNAPOLBAKR1B1CNR2HDAC6 | |
| SCHEMBL1786577 | 0.85 | LMNA (0.52) | LMNAPOLBAKR1B1CNR2HDAC6 | |
| SCHEMBL13721432 | 0.82 | LMNA (0.50) | LMNAPOLBAKR1B1CNR2USP2 | |
| SCHEMBL13720169 | 0.80 | ALDH1A1 (0.48) | LMNAPOLBAKR1B1CNR2USP2 | |
| SCHEMBL30814174 | 0.78 | MEN1 (0.45) | LMNAPOLBAKR1B1CNR2KMT2A | |
| SCHEMBL1789193 | 0.78 | MEN1 (0.45) | LMNAPOLBAKR1B1CNR2KMT2A | |
| SCHEMBL13721151 | 0.77 | PPARA (0.45) | LMNAPOLBAKR1B1CNR2USP2 | |
| SCHEMBL30794862 | 0.77 | TP53 (0.54) | LMNAPOLBCNR2KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859549-B2 | Potassium channel modulators | ABBVIE, INC. (US) | 2014-10-14 | — | — | US | claimed |
| US-8859549-B2 | Potassium channel modulators | ABBVIE, INC. (US) | 2014-10-14 | — | — | US | disclosed |