Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29978511 | 1.00 | ALDH1A1 (0.38) | ALDH1A1KDM4EPOLBNPC1RAB9A | |
| SCHEMBL1180456 | 0.84 | KDM4E (0.52) | ALDH1A1KDM4ESMN1; SMN2KMT2AGABRP | |
| SCHEMBL20934640 | 0.84 | NPC1 (0.39) | ALDH1A1KDM4EPOLBNPC1RAB9A | |
| SCHEMBL1643576 | 0.83 | NOS3 (0.44) | ALDH1A1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30024345 | 0.83 | NOS3 (0.44) | ALDH1A1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17841571 | 0.82 | POLB (0.38) | ALDH1A1KDM4EPOLBNPC1RAB9A | |
| SCHEMBL3120938 | 0.82 | TSHR (0.42) | ALDH1A1KDM4EPOLBKMT2AGABRP | |
| Potassium Ion SCHEMBL13731040 | 0.81 | KDM4E (0.36) | ALDH1A1KDM4EPOLBNPC1RAB9A | |
| SCHEMBL25521952 | 0.80 | UHRF1 (0.52) | ALDH1A1KDM4EPOLBNPC1RAB9A | |
| SCHEMBL24665060 | 0.79 | HPGD (0.36) | ALDH1A1KDM4EPOLBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022236319-A1 | NAPHTHYRIDONE COMPOUNDS FOR INHIBITION OF RAF KINASES AND/OR BCR-ABL TYROSINE KINASES | ENLIVEN THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |
| EP-2709983-B1 | INSECTICIDAL COMPOUNDS BASED ON ARYLTHIOACETAMIDE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2018-04-18 | — | — | EP | disclosed |
| EP-2709983-B1 | INSECTICIDAL COMPOUNDS BASED ON ARYLTHIOACETAMIDE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2018-04-18 | — | — | EP | disclosed |
| US-20160304506-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS CRAC MODULATORS | LUPIN LIMITED (IN) | 2016-10-20 | — | — | US | disclosed |
| US-9399638-B2 | Substituted pyridine compounds as CRAC modulators | LUPIN LIMITED (IN) | 2016-07-26 | — | — | US | disclosed |
| US-20150111900-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS CRAC MODULATORS | LUPIN LIMITED (IN) | 2015-04-23 | — | — | US | disclosed |
| US-8895587-B2 | Insecticidal compounds based on arylthioacetamide derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2014-11-25 | — | — | US | disclosed |
| US-8895587-B2 | Insecticidal compounds based on arylthioacetamide derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2014-11-25 | — | — | US | disclosed |
| US-8895587-B2 | Insecticidal compounds based on arylthioacetamide derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2014-11-25 | — | — | US | disclosed |
| US-20140107161-A1 | INSECTICIDAL COMPOUNDS BASED ON ARYLTHIOACETAMIDE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2014-04-17 | — | — | US | disclosed |
| US-20140107161-A1 | INSECTICIDAL COMPOUNDS BASED ON ARYLTHIOACETAMIDE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2014-04-17 | — | — | US | disclosed |
| US-20140107161-A1 | INSECTICIDAL COMPOUNDS BASED ON ARYLTHIOACETAMIDE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2014-04-17 | — | — | US | disclosed |
| EP-2709983-A1 | INSECTICIDAL COMPOUNDS BASED ON ARYLTHIOACETAMIDE DERIVATIVES | Syngenta Participations AG (CH) | 2014-03-26 | — | — | EP | disclosed |
| WO-2012156400-A1 | INSECTICIDAL COMPOUNDS BASED ON ARYLTHIOACETAMIDE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150111900-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS CRAC MODULATORS | ORAI1, RYR2, RYR1 | ALDH1A1 2188/4885KDM4E 2333/4885POLB 4828/4885 |
| US-20160304506-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS CRAC MODULATORS | ORAI1, RYR2, RYR1 | ALDH1A1 2188/4885KDM4E 2333/4885POLB 4828/4885 |
| US-20140107161-A1 | INSECTICIDAL COMPOUNDS BASED ON ARYLTHIOACETAMIDE DERIVATIVES | NAT1, ACHE, CHRM1 | ALDH1A1 91/4885KDM4E 1954/4885POLB 4590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.