SCHEMBL13860281

SCHEMBL13860281

O=C(NCc1c[nH]c2ncccc12)c1ccccn1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.60
MTNR1A P48039 1/20 0.54
TSHR P16473 1/20 0.54
ADORA2A P29274 1/20 0.54
GPR84 Q9NQS5 2/20 0.54
MET P08581 1/20 0.51
KMT2A Q03164 2/20 0.50
HPGD P15428 1/20 0.50
MAPK1 P28482 1/20 0.50
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2C19 P33261 1/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
HDAC3 O15379 1/20 0.47
HDAC4 P56524 1/20 0.47
HDAC1 Q13547 1/20 0.47
HDAC7 Q8WUI4 1/20 0.47
HDAC2 Q92769 1/20 0.47
HDAC10 Q969S8 1/20 0.47
HDAC11 Q96DB2 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27033531 0.82 GPR84 (0.61) MTNR1AADORA2AGPR84METKMT2A
SCHEMBL1362109 0.81 HPGD (0.54) HTTMTNR1AADORA2AGPR84MET
SCHEMBL27581164 0.81 GPR84 (0.59) MTNR1AADORA2AGPR84METKMT2A
SCHEMBL7983367 0.81 MTNR1A (0.53) MTNR1AADORA2AGPR84METKMT2A
SCHEMBL7998339 0.80 MET (0.63) MTNR1AADORA2AGPR84METKMT2A
SCHEMBL7975613 0.80 TSHR (0.68) HTTTSHRKMT2AHPGDMAPK1
SCHEMBL858139 0.80 NPC1 (0.60) MTNR1AADORA2AGPR84METKMT2A
SCHEMBL858653 0.79 SMN1; SMN2 (0.51) MTNR1AADORA2AGPR84METKMT2A
SCHEMBL857650 0.79 HPGD (0.51) HTTMTNR1ATSHRADORA2AGPR84
SCHEMBL878897 0.78 NPC1 (0.56) HTTMTNR1AADORA2AGPR84MET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2709622-A2 KINASE MODULATION AND INDICATIONS THEREFOR PLEXXIKON INC. (US) 2014-03-26 EP disclosed
WO-2012158957-A2 KINASE MODULATION AND INDICATIONS THEREFOR PLEXXIKON INC. (US) 2012-11-22 WO disclosed