Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | FABP7 | O15540 | 1/20 | 0.35 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5688782 | 1.00 | GAA (0.57) | GAAMAPTEPHX2BRD4CREBBP | |
| SCHEMBL5688979 | 1.00 | GAA (0.57) | GAAMAPTEPHX2BRD4CREBBP | |
| Hydrochloric Acid SCHEMBL7313114 | 0.98 | GAA (0.56) | GAAMAPTEPHX2BRD4CREBBP | |
| SCHEMBL9408124 | 0.90 | GAA (0.48) | GAAMAPT | |
| SCHEMBL27477039 | 0.85 | GAA (0.51) | GAAMAPTEPHX2BRD4CREBBP | |
| SCHEMBL8120364 | 0.85 | GAA (0.51) | GAAMAPTEPHX2BRD4CREBBP | |
| SCHEMBL6211215 | 0.83 | MAPT (0.46) | GAAMAPTMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL2487417 | 0.82 | GAA (0.49) | GAAMAPTEPHX2BRD4CREBBP | |
| SCHEMBL8444853 | 0.82 | GAA (0.49) | GAAMAPTEPHX2BRD4CREBBP | |
| SCHEMBL27604666 | 0.80 | GAA (0.46) | GAAMAPTEPHX2BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4800482-B2 | — | — | 2011-10-26 | — | — | JP | claimed |
| EP-1833789-B1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED INDOLINE-2-CARBOXYLIC ACID | DSM IP ASSETS BV (NL) | 2011-07-06 | — | — | EP | claimed |
| EP-1294689-B1 | PREPARATION METHOD OF A NOVEL BETA CRYSTALLINE FORM OF PERINDOPRIL TERT-BUTYLAMINE SALT | SERVIER LAB (FR) | 2006-04-26 | — | — | EP | claimed |
| EP-1348684-B1 | Method for synthesis of (2S)-indoline-2-carboxylic acid; and use in the synthesis of perindopril | SERVIER LAB (FR) | 2006-03-08 | — | — | EP | claimed |
| EP-0937714-B1 | Process for the preparation of an optically active indoline-2-carboxylic acid or derivative thereof | DSM IP ASSETS BV (NL) | 2004-10-06 | — | — | EP | claimed |
| EP-1140826-A1 | METHOD FOR PRODUCING (2S,4R,9S)-OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID AND INTERMEDIATE PRODUCTS THEREFOR | BASF AKTIENGESELLSCHAFT (DE) | 2001-10-10 | — | — | EP | claimed |
| WO-2000040555-A1 | METHOD FOR PRODUCING (2S,4R,9S)-OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID AND INTERMEDIATE PRODUCTS THEREFOR | BASF AKTIENGESELLSCHAFT (DE) | 2000-07-13 | — | — | WO | claimed |
| EP-0793674-B1 | HUMAN NEUTROPHIL ELASTASE INHIBITORS | CORTECH INC (US) | 2000-05-24 | — | — | EP | claimed |
| EP-0920307-A2 | DERIVATES FROM BISARYLTETRACARBONACID, AND PHARMARCEUTICAL PRODUCT CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1999-06-09 | — | — | EP | claimed |
| WO-1998006386-A2 | DERIVATES FROM BISARYLTETRACARBONACID, AND PHARMARCEUTICAL PRODUCT CONTAINING THEM | ROCHE DIAGNOSTICS GMBH (DE) | 1998-02-19 | — | — | WO | claimed |
| EP-0521827-B1 | Pharmacological active hydrazin derivatives and process for their preparation | CIBA GEIGY AG (CH) | 1996-09-25 | — | — | EP | claimed |
| EP-0604368-B1 | Anti retroviral hydrazine derivatives | CIBA GEIGY AG (CH) | 1996-09-18 | — | — | EP | claimed |
| EP-0604368-A1 | Anti retroviral hydrazine derivatives | CIBA-GEIGY AG (CH) | 1994-06-29 | — | — | EP | claimed |
| EP-0521827-A1 | Pharmacological active hydrazin derivatives and process for their preparation | CIBA-GEIGY AG (CH) | 1993-01-07 | — | — | EP | claimed |
| EP-0197474-B1 | PROCESS FOR PREPARING OPTICALLY ACTIVE INDOLINE-2-CARBOXYLIC ACID | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1991-07-10 | — | — | EP | claimed |
| EP-0236734-A2 | 5-Amino-4-hydroxyvaleryl derivatives substituted by s-containing groups | CIBA-GEIGY AG (CH) | 1987-09-16 | — | — | EP | claimed |
| EP-0184550-A2 | 5-Amino-4-hydroxy valeryl amide derivatives | CIBA-GEIGY AG (CH) | 1986-06-11 | — | — | EP | claimed |
| EP-2225223-B1 | ORGANIC COMPOUNDS | BOEHRINGER INGELHEIM INT (DE) | 2017-01-11 | — | — | EP | disclosed |
| EP-0029488-A1 | Amino acid derivatives, process for their preparation and their use in treating hypertension | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-06-03 | — | — | EP | disclosed |
| EP-0001546-A1 | 2-Guanidinomethyl-indolines, method for their preparation and their pharmaceutical use | Merck Patent GmbH (DE) | 1979-05-02 | — | — | EP | disclosed |