Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8444853 | 1.00 | GAA (0.49) | GAAMAPTMTNR1AMTNR1BEPHX2 | |
| SCHEMBL27477039 | 0.84 | GAA (0.51) | GAAMAPTMTNR1AMTNR1BEPHX2 | |
| SCHEMBL3043496 | 0.84 | MAPT (0.45) | GAAMAPTMTNR1AMTNR1BBRD4 | |
| Hydrochloric Acid SCHEMBL3052246 | 0.82 | MAPT (0.44) | GAAMAPTMTNR1AMTNR1BBRD4 | |
| SCHEMBL1386080 | 0.82 | GAA (0.57) | GAAMAPTMTNR1AMTNR1BEPHX2 | |
| SCHEMBL5688979 | 0.82 | GAA (0.57) | GAAMAPTMTNR1AMTNR1BEPHX2 | |
| SCHEMBL5688782 | 0.82 | GAA (0.57) | GAAMAPTMTNR1AMTNR1BEPHX2 | |
| Hydrochloric Acid SCHEMBL7313114 | 0.81 | GAA (0.56) | GAAMAPTMTNR1AMTNR1BEPHX2 | |
| SCHEMBL8120364 | 0.81 | GAA (0.51) | GAAMAPTMTNR1AMTNR1BEPHX2 | |
| SCHEMBL9242621 | 0.80 | ROCK2 (0.33) | GAAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150530-B1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2011-10-26 | — | — | EP | disclosed |
| EP-2150530-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008131947-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | disclosed |