Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 3/20 | 0.53 |
| ▸ | ERCC4 | Q92889 | 3/20 | 0.53 |
| ▸ | ARG1 | P05089 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | ALPL | P05186 | 1/20 | 0.45 |
| ▸ | ALPG | P10696 | 1/20 | 0.45 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL109025 | 1.00 | ERCC1 (0.53) | ERCC1ERCC4ARG1FYNMEN1 | |
| SCHEMBL8346672 | 0.91 | HRH3 (0.61) | ERCC1ERCC4ARG1MEN1KMT2A | |
| SCHEMBL15458910 | 0.83 | ERCC1 (0.43) | ERCC1ERCC4ARG1FYNCA1 | |
| SCHEMBL10912805 | 0.81 | MAPT (0.58) | CA1CA2CA4CA6HRH3 | |
| SCHEMBL139478 | 0.81 | ERCC1 (0.58) | ERCC1ERCC4ARG1CA1CA2 | |
| SCHEMBL8231045 | 0.81 | ERCC1 (0.58) | ERCC1ERCC4ARG1CA1CA2 | |
| SCHEMBL108594 | 0.81 | ERCC1 (0.58) | ERCC1ERCC4ARG1CA1CA2 | |
| SCHEMBL22953954 | 0.81 | FYN (0.57) | ERCC1ERCC4ARG1FYNKDM4E | |
| SCHEMBL10285598 | 0.81 | QDPR (0.55) | ERCC1ERCC4KDM4EALDH1A1MAPT | |
| SCHEMBL10073807 | 0.79 | MEN1 (0.69) | MEN1RAB9AKMT2AHRH3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895554-B2 | Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as Alzheimer's disease, type 2 diabetes, and Parkinson's disease | PROTEOTECH INC (US) | 2014-11-25 | — | — | US | disclosed |
| US-8895554-B2 | Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as Alzheimer's disease, type 2 diabetes, and Parkinson's disease | PROTEOTECH INC (US) | 2014-11-25 | — | — | US | disclosed |
| US-7514583-B2 | bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs; treatment of A beta , IAPP, other amyloids, and alpha -synuclein or NAC fibrillogenesis | PROTEOTECH, INC. (US) | 2009-04-07 | — | — | US | disclosed |