Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 6/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13886696 | 0.83 | CXCR2 (0.53) | ALDH1A1GAATSHRMAPTSMN1; SMN2 | |
| SCHEMBL13869872 | 0.82 | PDE4D (0.54) | ALDH1A1HTTMAPK1GAAUSP2 | |
| SCHEMBL3987717 | 0.80 | ALDH1A1 (0.56) | ALDH1A1HTTMAPK1GAAUSP2 | |
| SCHEMBL3982213 | 0.77 | ALDH1A1 (0.52) | ALDH1A1HTTMAPK1GAAUSP2 | |
| SCHEMBL3990317 | 0.77 | THRB (0.57) | ALDH1A1HTTMAPK1GAAUSP2 | |
| SCHEMBL13886697 | 0.76 | ALDH1A1 (0.48) | ALDH1A1HTTMAPK1GAAUSP2 | |
| SCHEMBL2306161 | 0.74 | MAPT (0.76) | ALDH1A1GAATSHRHPGDMAPT | |
| SCHEMBL13779376 | 0.74 | ALDH1A1 (0.81) | ALDH1A1GAATSHRHPGDMAPT | |
| SCHEMBL3982274 | 0.74 | ALDH1A1 (0.53) | ALDH1A1HTTMAPK1GAAUSP2 | |
| SCHEMBL5484664 | 0.73 | ALDH1A1 (0.50) | ALDH1A1HTTMAPK1GAAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524853-B2 | Compounds and their use in therapy | SOLVAY PHARMACEUTICALS B.V. (NL) | 2009-04-28 | — | — | US | disclosed |
| US-7524853-B2 | Compounds and their use in therapy | SOLVAY PHARMACEUTICALS B.V. (NL) | 2009-04-28 | — | — | US | disclosed |
| US-7465739-B2 | Compounds and their use in therapy | SOLVAY PHARMACEUTICALS B.V. (NL) | 2008-12-16 | — | — | US | disclosed |
| US-7465739-B2 | Compounds and their use in therapy | SOLVAY PHARMACEUTICALS B.V. (NL) | 2008-12-16 | — | — | US | disclosed |