Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | TDO2 | P48775 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14818581 | 0.91 | PTK2 (0.33) | HTR7L3MBTL1CYP2A6KDM4ENPC1 | |
| SCHEMBL13872134 | 0.91 | PRKCI (0.38) | HTR7HSD17B10CYP2A6FAAHKDM4E | |
| SCHEMBL13871897 | 0.89 | OXER1 (0.33) | L3MBTL1CYP2A6 | |
| SCHEMBL13113714 | 0.86 | HTR7 (0.37) | HTR7L3MBTL1CYP2A6FAAHKDM4E | |
| SCHEMBL13872127 | 0.86 | HTR7 (0.43) | HTR7HSD17B10 | |
| SCHEMBL13872204 | 0.85 | HTR7 (0.33) | HTR7HSD17B10 | |
| SCHEMBL13872167 | 0.85 | KDM2B (0.32) | IDO1TDO2 | |
| SCHEMBL13872271 | 0.84 | PRKCI (0.43) | L3MBTL1CYP2A6EGFRIDO1TDO2 | |
| SCHEMBL13872211 | 0.84 | CYP2A6 (0.35) | HTR7CYP2A6KDM4ENPC1RAB9A | |
| SCHEMBL13871874 | 0.83 | CYP2A6 (0.34) | CYP2A6EGFRIDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009042907-A1 | ISOINDOLINE COMPOUNDS FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY AND OTHER USES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-04-02 | — | — | WO | disclosed |