Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 3/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
| ▸ | YES1 | P07947 | 1/20 | 0.30 |
| ▸ | FGR | P09769 | 1/20 | 0.30 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13871896 | 0.91 | HTR7 (0.37) | HTR7KDM4ENPC1RAB9AL3MBTL1 | |
| SCHEMBL13871897 | 0.83 | OXER1 (0.33) | MCHR1DRD2HTR6L3MBTL1CYP2A6 | |
| SCHEMBL13872134 | 0.82 | PRKCI (0.38) | HTR7MCHR1KDM4ENPC1RAB9A | |
| SCHEMBL13872211 | 0.81 | CYP2A6 (0.35) | HTR7KDM4ENPC1RAB9ACYP2A6 | |
| SCHEMBL13872271 | 0.81 | PRKCI (0.43) | DRD2MAPKAPK2L3MBTL1CYP2A6 | |
| SCHEMBL13871874 | 0.80 | CYP2A6 (0.34) | CYP2A6 | |
| SCHEMBL13872167 | 0.79 | KDM2B (0.32) | — | |
| SCHEMBL13872127 | 0.78 | HTR7 (0.43) | HTR7 | |
| SCHEMBL13871967 | 0.78 | HTR6 (0.43) | MAPK1DRD2HTR6KDM4ENPC1 | |
| SCHEMBL13113714 | 0.78 | HTR7 (0.37) | HTR7MCHR1MAPK1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2573080-A1 | Isoindoline compounds for the treatment of spinal muscular atrophy and other uses | The United States of America, as Represented by the Secretary, Department of Health and Human Services (US) | 2013-03-27 | — | — | EP | disclosed |