Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.43 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 4/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13872258 | 0.89 | LRRK2 (0.41) | FAAHLRRK2DRD2CCNCCDK8 | |
| SCHEMBL13113569 | 0.88 | MAP3K5 (0.51) | CYP11B1CYP11B2MAP3K5FAAHLRRK2 | |
| SCHEMBL13872303 | 0.83 | MAP3K5 (0.43) | CYP11B1CYP11B2MAP3K5HTR1DCYP1A2 | |
| SCHEMBL3481109 | 0.80 | MAP3K5 (0.51) | CYP11B1CYP11B2MAP3K5HTR1DCYP1A2 | |
| SCHEMBL13872246 | 0.79 | CYP11B1 (0.43) | CYP11B1CYP11B2MAP3K5CYP1A2 | |
| SCHEMBL13872269 | 0.78 | PRKCI (0.40) | FAAHLRRK2KDM4EMAPT | |
| SCHEMBL13872131 | 0.78 | PRKCI (0.42) | FAAHMEN1TP53CYP2D6MAPT | |
| SCHEMBL23187978 | 0.78 | CYP11B2 (0.64) | CYP11B1CYP11B2FAAHHTR1DKDM4E | |
| SCHEMBL13872217 | 0.77 | PRKCI (0.39) | FAAHLRRK2HTR2C | |
| SCHEMBL13871952 | 0.77 | PRKCI (0.39) | FAAHLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009042907-A1 | ISOINDOLINE COMPOUNDS FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY AND OTHER USES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-04-02 | — | — | WO | disclosed |