Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 13/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 12/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.39 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13871876 | 0.89 | NOTUM (0.35) | CYP11B1CYP11B2 | |
| SCHEMBL13871907 | 0.88 | MAP3K5 (0.49) | CYP11B1CYP11B2CYP1A2CYP17A1CYP19A1 | |
| SCHEMBL13871899 | 0.87 | MCHR1 (0.37) | CYP11B1CYP11B2SRD5A1 | |
| SCHEMBL13871851 | 0.79 | NPC1 (0.37) | — | |
| SCHEMBL13872207 | 0.79 | CYP11B1 (0.43) | CYP11B1CYP11B2CYP1A2MAP3K5 | |
| SCHEMBL13872303 | 0.78 | MAP3K5 (0.43) | CYP11B1CYP11B2CYP1A2CYP17A1CYP19A1 | |
| SCHEMBL13871856 | 0.77 | CYP1A2 (0.35) | CYP1A2 | |
| SCHEMBL13871879 | 0.77 | HTR2C (0.37) | CYP1A2 | |
| SCHEMBL21646417 | 0.73 | CYP11B2 (0.66) | CYP11B1CYP11B2CYP1A2CYP17A1CYP19A1 | |
| SCHEMBL13871887 | 0.73 | NOTUM (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009042907-A1 | ISOINDOLINE COMPOUNDS FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY AND OTHER USES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-04-02 | — | — | WO | disclosed |