Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.43 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13113767 | 0.88 | MAP3K5 (0.54) | MAP3K5TDP2CYP11B1CYP11B2CYP17A1 | |
| SCHEMBL13872280 | 0.88 | MCHR1 (0.36) | MAP3K5 | |
| SCHEMBL13872207 | 0.83 | CYP11B1 (0.43) | MAP3K5TDP2CYP11B1CYP11B2DRD2 | |
| SCHEMBL13872246 | 0.78 | CYP11B1 (0.43) | MAP3K5CYP11B1CYP11B2CYP17A1CYP19A1 | |
| SCHEMBL13113755 | 0.75 | MCHR1 (0.48) | MAP3K5 | |
| SCHEMBL13872274 | 0.73 | MEN1 (0.32) | CYP1A2 | |
| SCHEMBL3481109 | 0.73 | MAP3K5 (0.51) | MAP3K5TDP2CYP11B1CYP11B2HTR1D | |
| SCHEMBL13872258 | 0.71 | LRRK2 (0.41) | DRD2 | |
| SCHEMBL13113569 | 0.71 | MAP3K5 (0.51) | MAP3K5TDP2CYP11B1CYP11B2CYP17A1 | |
| SCHEMBL13872273 | 0.71 | METAP1 (0.35) | CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009042907-A1 | ISOINDOLINE COMPOUNDS FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY AND OTHER USES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-04-02 | — | — | WO | disclosed |