⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38654455 | 0.87 | ALDH1A1 (0.42) | — | |
| SCHEMBL9795517 | 0.86 | NAAA (0.44) | — | |
| SCHEMBL4760493 | 0.84 | — | — | |
| SCHEMBL9497894 | 0.84 | GAA (0.44) | — | |
| SCHEMBL11783132 | 0.82 | GAA (0.47) | — | |
| SCHEMBL14198853 | 0.82 | SLC6A5 (0.49) | — | |
| SCHEMBL622441 | 0.81 | — | — | |
| SCHEMBL1387385 | 0.80 | — | — | |
| SCHEMBL10057792 | 0.80 | SLC6A5 (0.51) | — | |
| SCHEMBL20710352 | 0.80 | SLC6A5 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733045-B1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | claimed |
| US-5880130-A | TREATMENT OF CELL-PROLIFERATION DISEASES | ZENECA LIMITED (GB) | 1999-03-09 | — | — | US | claimed |
| JP-H09506363-A | — | — | 1997-06-24 | — | — | JP | claimed |
| EP-0733045-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | claimed |
| WO-1995015952-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1995-06-15 | — | — | WO | claimed |
| US-9416195-B2 | Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2016-08-16 | — | — | US | disclosed |
| US-20130224225-A1 | ANTIBODIES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME USEFUL FOR INHIBITING ACTIVITY OF METALLOPROTEINS | YEDA RESEARCH AND DEVELOPMENT CO., LTD. (IL) | 2013-08-29 | — | — | US | disclosed |
| US-8486653-B2 | Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2013-07-16 | — | — | US | disclosed |
| US-20130030158-A1 | ANTIBODIES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME USEFUL FOR INHIBITING ACTIVITY OF METALLOPROTEINS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2013-01-31 | — | — | US | disclosed |
| EP-2165830-B1 | Lithographic printing plate precursor and printing method using the same | FUJIFILM CORP (JP) | 2011-03-16 | — | — | EP | disclosed |
| EP-0733045-B1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| EP-0733045-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015952-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1995-06-15 | — | — | WO | disclosed |