Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 9/20 | 0.42 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19806337 | 0.82 | TGFBR1 (0.51) | TGFBR1ADORA2ANAMPTPDE4APDE3A | |
| SCHEMBL13874308 | 0.77 | FLT3 (0.34) | TGFBR1ADORA2AFLT3 | |
| SCHEMBL19806362 | 0.76 | TGFBR1 (0.47) | TGFBR1PDE4APDE3ACYP3A4HPGD | |
| SCHEMBL3846702 | 0.76 | RORC (0.39) | TGFBR1RORCADORA2ANAMPTPOLB | |
| SCHEMBL19806599 | 0.74 | TGFBR1 (0.37) | TGFBR1PDE10AADORA2A | |
| SCHEMBL19806323 | 0.73 | ADORA2A (0.41) | TGFBR1ADORA2A | |
| Hydrochloric Acid SCHEMBL3847655 | 0.73 | FLT3 (0.53) | FLT3 | |
| SCHEMBL15638811 | 0.71 | TGFBR1 (0.45) | TGFBR1RORCAXLFLT3MERTK | |
| SCHEMBL3160320 | 0.70 | MAPK14 (0.42) | AXLNFKB1HSD17B10 | |
| SCHEMBL19806491 | 0.70 | TGFBR1 (0.50) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |