Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 9/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | FRK | P42685 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3845543 | 0.84 | TGFBR1 (0.47) | TGFBR1ADORA2AADORA2BADORA1NAMPT | |
| SCHEMBL3846676 | 0.82 | ADORA2A (0.36) | TGFBR1CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL3846704 | 0.82 | RORC (0.34) | RORCTGFBR1 | |
| SCHEMBL3850256 | 0.80 | FLT3 (0.34) | CSNK1DCSNK1EMAPK11MAPK14 | |
| SCHEMBL3849569 | 0.78 | CDK1 (0.36) | TGFBR1CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL3850113 | 0.76 | SMN1; SMN2 (0.38) | TGFBR1CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL13874255 | 0.76 | TGFBR1 (0.42) | RORCTGFBR1POLBADORA2ANAMPT | |
| SCHEMBL3851177 | 0.74 | TGFBR1 (0.47) | TGFBR1ADORA2AADORA2BADORA1 | |
| SCHEMBL3847660 | 0.73 | TGFBR1 (0.43) | TGFBR1 | |
| SCHEMBL3852193 | 0.73 | TGFBR1 (0.40) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |