Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | CHKA | P35790 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27656180 | 0.81 | MAPK14 (0.46) | MAPK14MAPK13CSNK1DCSNK1EMAPK12 | |
| SCHEMBL1554588 | 0.81 | CSNK1D (0.57) | HTR2AMAPK14MAPK13CSNK1DCSNK1E | |
| SCHEMBL9933095 | 0.79 | SMN1; SMN2 (0.49) | HTR2AAHRMAPK14MAPK13CSNK1D | |
| SCHEMBL13481172 | 0.79 | RAB9A (0.43) | AHRMAPK14MAPK13CSNK1DCSNK1E | |
| SCHEMBL4128565 | 0.79 | MAPK13 (0.54) | MAPK14MAPK13CSNK1DCSNK1EMAPK12 | |
| SCHEMBL4309166 | 0.77 | KEAP1 (0.47) | MAPK14MAPK13CSNK1DCSNK1EMAPK12 | |
| SCHEMBL15885797 | 0.77 | BRAF (0.46) | MAPK14MAPK13CSNK1DCSNK1EMAPK12 | |
| SCHEMBL3922875 | 0.77 | L3MBTL1 (0.48) | HTR2AMAPK14MAPK13CSNK1DCSNK1E | |
| SCHEMBL17295105 | 0.76 | SMN1; SMN2 (0.49) | MAPK14MAPK13CSNK1DCSNK1EMAPK12 | |
| SCHEMBL5463467 | 0.76 | MAPK13 (0.73) | MAPK14MAPK13CSNK1DCSNK1EMAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |