SCHEMBL2102844

SCHEMBL2102844

O=C(Nc1c(Br)cc(SC(F)(F)C(F)(F)C(F)(F)F)cc1Br)c1cccc(NC(=O)c2cccnc2Cl)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51
ALDH1A1 P00352 3/20 0.44
MAPT P10636 3/20 0.41
MAPK1 P28482 1/20 0.41
CSF1R P07333 3/20 0.40
KDM4E B2RXH2 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
GFER P55789 1/20 0.39
PTGES O14684 1/20 0.39
RXFP1 Q9HBX9 3/20 0.38
CES1 P23141 1/20 0.38
RHOC P08134 1/20 0.38
RHOA P61586 1/20 0.38
KCNK3 O14649 1/20 0.37
KCNK9 Q9NPC2 1/20 0.37
NPC1 O15118 1/20 0.37
CASP3 P42574 1/20 0.37
RAB9A P51151 1/20 0.37
SENP8 Q96LD8 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1361068 0.89 MEN1 (0.48) MEN1KMT2AALDH1A1MAPTMAPK1
SCHEMBL1767081 0.86 MEN1 (0.53) MEN1KMT2AALDH1A1MAPTMAPK1
SCHEMBL2107104 0.84 KCNK3 (0.49) MEN1KMT2AMAPTKCNK3KCNK9
SCHEMBL1829876 0.84 MEN1 (0.54) MEN1KMT2AALDH1A1MAPTMAPK1
SCHEMBL18023939 0.81 MEN1 (0.53) MEN1KMT2AALDH1A1MAPTMAPK1
SCHEMBL18023941 0.81 MEN1 (0.53) MEN1KMT2AALDH1A1MAPTMAPK1
SCHEMBL4187726 0.80 MEN1 (0.48) MEN1KMT2AALDH1A1MAPTMAPK1
SCHEMBL1767273 0.80 MEN1 (0.48) MEN1KMT2AALDH1A1MAPTMAPK1
SCHEMBL13875604 0.80 KMT2A (0.50) MEN1KMT2AALDH1A1MAPTMAPK1
SCHEMBL18023938 0.80 MEN1 (0.57) MEN1KMT2AALDH1A1MAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230373947-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE MITSUI CHEMICALS, INC. (JP) 2023-11-23 US disclosed
US-11760742-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide MITSUI CHEMICALS, INC. (JP) 2023-09-19 US disclosed
US-20210230135-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE MITSUI CHEMICALS, INC. (JP) 2021-07-29 US disclosed
US-10995081-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide MITSUI CHEMICALS, INC. (JP) 2021-05-04 US disclosed
US-10435385-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide MITSUI CHEMICALS, INC. (JP) 2019-10-08 US disclosed
US-20180134681-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE MITSUI CHEMICALS, INC. (JP) 2018-05-17 US disclosed
US-9920026-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide MITSUI CHEMICALS, INC. (JP) 2018-03-20 US disclosed
EP-1714958-B9 AMIDE DERIVATIVES, PROCESS FOR PRODUCTION OF THE SAME, AND METHOD FOR APPLICATION THEREOF AS INSECTICIDE MITSUI CHEMICALS AGRO INC (JP) 2017-05-31 EP disclosed
EP-1714958-B1 AMIDE DERIVATIVES, PROCESS FOR PRODUCTION OF THE SAME, AND METHOD FOR APPLICATION THEREOF AS INSECTICIDE MITSUI CHEMICALS AGRO INC (JP) 2016-12-21 EP disclosed
US-20160002198-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE MITSUI CHEMICALS, INC. (JP) 2016-01-07 US disclosed
US-8563736-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide MITSUI CHEMICALS, INC. (JP) 2013-10-22 US disclosed
US-20120225891-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE MITSUI CHEMICALS, INC. (JP) 2012-09-06 US disclosed
US-8168825-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide MITSUI CHEMICALS, INC. (JP) 2012-05-01 US disclosed
US-8163804-B2 Composition for preventing harmful organisms MITSUI CHEMICALS, INC. (JP) 2012-04-24 US disclosed
US-20090192167-A1 Insecticidal and fungicidal composition MITSUI CHEMICALS, INC. (JP) 2009-07-30 US disclosed
US-20090162453-A1 COMPOSITION FOR PREVENTING HARMFUL ORGANISMS MITSUI CHEMICALS, INC (JP) 2009-06-25 US disclosed
EP-1938685-A1 INSECTICIDAL AND BACTERICIDAL COMPOSITION Mitsui Chemicals, Inc. (JP) 2008-07-02 EP disclosed
EP-1913815-A1 PEST CONTROL COMPOSITION Mitsui Chemicals, Inc. (JP) 2008-04-23 EP disclosed
US-20070275980-A1 Amide Derivatives, Process For Preparation Thereof And Use Thereof As Insecticide MITSUI CHEMICALS, INC. (JP) 2007-11-29 US disclosed
EP-1714958-A1 AMIDE DERIVATIVES, PROCESS FOR PRODUCTION OF THE SAME, AND METHOD FOR APPLICATION THEREOF AS INSECTICIDE Mitsui Chemicals, Inc. (JP) 2006-10-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070275980-A1 Amide Derivatives, Process For Preparation Thereof And Use Thereof As Insecticide CYP1A1, CYP4B1, CYP2E1 MEN1 3376/4885KMT2A 1782/4885ALDH1A1 238/4885
US-20180134681-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE CYP1A1, CYP4B1, CYP2E1 MEN1 3376/4885KMT2A 1782/4885ALDH1A1 238/4885
US-20120225891-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE DDT, CYP4B1, CYP2E1 MEN1 2759/4885KMT2A 565/4885ALDH1A1 103/4885
US-20160002198-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE CYP1A1, CYP4B1, CYP2E1 MEN1 3376/4885KMT2A 1782/4885ALDH1A1 238/4885
US-20090192167-A1 Insecticidal and fungicidal composition NOX3, PRDX1, CYP4X1 MEN1 1780/4885KMT2A 2083/4885ALDH1A1 1359/4885
US-20230373947-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE DDT, CYP4B1, CYP2E1 MEN1 2759/4885KMT2A 565/4885ALDH1A1 103/4885
US-20210230135-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE DDT, CYP4B1, CYP2E1 MEN1 2759/4885KMT2A 565/4885ALDH1A1 103/4885
US-10435385-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide DDT, CYP4B1, CYP2E1 MEN1 2759/4885KMT2A 565/4885ALDH1A1 103/4885
US-20090162453-A1 COMPOSITION FOR PREVENTING HARMFUL ORGANISMS PRDX3, CYP1A1, GSTA1 MEN1 485/4885KMT2A 1594/4885ALDH1A1 406/4885
US-11760742-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide DDT, CYP4B1, CYP2E1 MEN1 2759/4885KMT2A 565/4885ALDH1A1 103/4885
US-10995081-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide DDT, CYP4B1, CYP2E1 MEN1 2759/4885KMT2A 565/4885ALDH1A1 103/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.